53520-19-7

Basic information

• Product Name: ((S)-1-phenyl-ethyl)-p-tolyl ether
• CAS NO: 53520-19-7
• Molecular Weight: 212.291
• Mol File: 53520-19-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: ((S)-1-phenyl-ethyl)-p-tolyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: ((S)-1-phenyl-ethyl)-p-tolyl ether(53520-19-7)
• EPA Substance Registry System: ((S)-1-phenyl-ethyl)-p-tolyl ether(53520-19-7)

Safety Data

• Hazardous Substances Data: 53520-19-7(Hazardous Substances Data)

Upstream product

• 106-44-5 p-cresol 
• 1459-15-0 (R)-1-chloro-1-phenylethane 
• 100-39-0 benzyl bromide 
• 834-25-3 4-methylphenyl benzyl ether 
• 74-88-4 methyl iodide 
• 98-85-1 1-Phenylethanol 
• 618-36-0 rac-methylbenzylamine 

Downstream Products

• 1817-67-0 (S)-4-methyl-2-(1-phenylethyl)phenol 

Relevant articles and documents

Selective catalytic synthesis of unsymmetrical ethers from the dehydrative etherification of two different alcohols

The cationic ruthenium-hydride complex [(C6H6)(PCy3)(CO)RuH]+BF4- catalyzes selective etherification of two different alcohols to form unsymmetrically substituted ethers. The catalytic method exhibits a broad substrate scope while tolerating a range of heteroatom functional groups in forming unsymmetrical ethers, and it is successfully used to directly synthesize a number of highly functionalized chiral nonracemic ethers.

α-Lithiobenzyloxy as a Directed Metalation Group in ortho-Lithiation Reactions

The α-lithiobenzyloxy group, easily generated from aryl benzyl ethers by selective α-lithiation with t-BuLi at low temperature, behaves as a directed metalation group (DMG) providing a direct access to o-lithiophenyl α-lithiobenzyl ethers. This ortho-directing effect is reinforced in substrates bearing an additional methoxy group at the meta position. The generated dianions can be reacted with a selection of electrophiles including carboxylic esters and dihalosilanes or germanes, which afford interesting benzofuran, sila(germa)dihydrobenzofuran, and silachroman derivatives from simple aryl benzyl ethers.

Kinetics and Mechanism of Nucleophilic Displacements with Heterocycles as Leaving Groups. Part 10. Reactions of s-Alkyl Primary Amines with Pyryliums

2,4,6-Triphenylpyrylium with s-alkylamines gives isolatable pyridiniums (which undergo SN2 substitution with nucleophiles and elimination to olefins). 2,4,6-triphenylpyrilium with 1-phenylethylamine and α-phenylbenzylamine forms the corresponding carbonium ions which may be trapped by nucleophiles.Isolated 1-cycloalkylbenzoquinoliniums (2) solvolyse by the SN1 mechanism (for five-, six- and seven-membered rings): for the cyclobutyl case an Sn2 reaction is also found.