83783-66-8Relevant articles and documents
Synthesis method of bacterial infection resistant medicine intermediate
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Paragraph 0027, (2018/07/30)
The invention belongs to the technical field of chemical medicine intermediate synthesis, and particularly relates to a synthesis method of a bacterial infection resistant medicine intermediate. Liquid ammonia and acrylic ester are used as raw materials for preparing a diester type secondary amine compound 1; then, through cyclization, piperidone is prepared; then, scientific reaction catalysts, temperature and time are used; substitution reaction of secondary amine and iso-propyl iodide is used; the target product is synthesized through six-step reaction; the yield of the whole route reachesup to 35 percent.
Tetrahydroisoxazolo[4,5-c]pyridine derivatives useful in the treatment of malfunctions of the acetylcholine or muscarinic systems
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, (2008/06/13)
The present invention relates to novel compounds of the following formula: STR1 individual isomers and pharmaceutically acceptable acid addition salts thereof, wherein R1 is hydrogen, alkyl or phenyl-lower alkyl, in which the phenyl group may be substituted with halogen, lower alkyl or lower alkoxy; R2 is alkyl, alkenyl, alkynyl or phenyl-lower alkyl, in which the phenyl group may be substituted with halogen, lower alkyl or lower alkoxy; and R4 is hydrogen or alkyl. The invention moreover relates to methods for the preparation of the compounds of formula I, to novel intermediates, to pharmaceutical compositions containing same and to methods for the treatment of disorders, caused by malfunction of the acetylcholine (AcCh) or muscarinic system, by administering a non-toxic effective amount of a compound of the formula I.
