83783-66-8

Upstream product

• 541-41-3 chloroformic acid ethyl ester 
• 107-06-2 1,2-dichloro-ethane 
• 140-88-5 ethyl acrylate 
• 3518-88-5 3,3'-imino-di-propionic acid diethyl ester 
• 51-79-6 urethane 

Downstream Products

• 29976-53-2 N-ethoxycarbonyl-4-piperidone 
• 41661-47-6 piperidin-4-one 
• 5355-68-0 1-Isopropyl-4-piperidone 

Relevant academic research and scientific papers

Synthesis method of bacterial infection resistant medicine intermediate

The invention belongs to the technical field of chemical medicine intermediate synthesis, and particularly relates to a synthesis method of a bacterial infection resistant medicine intermediate. Liquid ammonia and acrylic ester are used as raw materials for preparing a diester type secondary amine compound 1; then, through cyclization, piperidone is prepared; then, scientific reaction catalysts, temperature and time are used; substitution reaction of secondary amine and iso-propyl iodide is used; the target product is synthesized through six-step reaction; the yield of the whole route reachesup to 35 percent.

Synthesis and characterization of N-substitutional ethylenediamine derivatives

N-Substituted and N,N-disubstituted ethylenediamine derivatives were prepared rapidly in aqueous conditions from 30 to 76 % yields, respectively, on a multi-gram scale starting from inexpensive and commercially available starting materials. The steps involved Michael addition, hydrazinolysis and Curtius rearrangements. The highlight of this method lies on its convenience and economy in accessing these intermediates.

Tetrahydroisoxazolo[4,5-c]pyridine derivatives useful in the treatment of malfunctions of the acetylcholine or muscarinic systems

The present invention relates to novel compounds of the following formula: STR1 individual isomers and pharmaceutically acceptable acid addition salts thereof, wherein R1 is hydrogen, alkyl or phenyl-lower alkyl, in which the phenyl group may be substituted with halogen, lower alkyl or lower alkoxy; R2 is alkyl, alkenyl, alkynyl or phenyl-lower alkyl, in which the phenyl group may be substituted with halogen, lower alkyl or lower alkoxy; and R4 is hydrogen or alkyl. The invention moreover relates to methods for the preparation of the compounds of formula I, to novel intermediates, to pharmaceutical compositions containing same and to methods for the treatment of disorders, caused by malfunction of the acetylcholine (AcCh) or muscarinic system, by administering a non-toxic effective amount of a compound of the formula I.