53555-41-2Relevant academic research and scientific papers
Thorpe–Ingold Effect in Branch-Selective Alkylation of Unactivated Aryl Fluorides
O'Neill, Matthew J.,Riesebeck, Tim,Cornella, Josep
supporting information, p. 9103 - 9107 (2018/07/24)
Presented herein is a general protocol for the alkylation of simple aryl fluorides with unbiased secondary Grignard reagents by means of nickel catalysis. This study revealed a general Thorpe–Ingold effect in the ligand backbone which confers a high degree of selectivity for the secondary carbon center in the C?C coupling event. This protocol is characterized by mild reaction conditions, robustness, and simplicity. Both electron-rich and electron-deficient aryl fluorides are suitable candidates in this transformation. Equally amenable are a variety of heterocycles, permitting the coupling without over alkylation at the electrophilic sites.
KETENE IMINE COMPOUND, POLYESTER FILM, BACK SHEET FOR SOLAR CELL MODULE AND SOLAR CELL MODULE
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Paragraph 0188; 0189, (2015/09/22)
By forming a polyester film from a polyester resin composition including ketene imine compound represented by the following Formula (1) and polyester, the polyester film having excellent hydrolysis resistance in which volatilization of the ketene imine co
9-AMINOMETHYL SUBSTITUTED TETRACYCLINE COMPOUND
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, (2014/06/24)
The present invention relates to 9-aminomethyl substituted tetracycline compounds represented by formula (I), or pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, as well as a method for preparing these compounds and a pharmaceutical composition comprising the same. The present invention relates also to a use of these compounds in the preparation of a medicament for the treatment and/or prophylaxis of tetracycline drug-sensitive disease. wherein, R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, R7, R8, R9a, R9b, R10, R11, R12, R13a and R13b are each independently as defined in the description.
9-AMINOMETHYL SUBSTITUTED TETRACYCLINE COMPOUNDS
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Page/Page column, (2014/07/08)
The present invention relates to 9-aminomethyl substituted tetracycline compounds represented by formula (I), or pharmaceutically acceptable salt, prodrug, solvate or isomer thereof, as well as a method for preparing these compounds and a pharmaceutical composition comprising the same. The present invention relates also to a use of these compounds in the preparation of a medicament for the treatment and/or prophylaxis of tetracycline drug-sensitive disease. wherein, R2a, R2b, R3, R4a, R4b, R5, R6a, R6b, R7, R8, R9a, R9b, R10, R11, R12, R13a and R13b are each independently as defined in the description.
BRIDGED BI-AROMATIC CATALYSTS, COMPLEXES, AND METHOD OF USING THE SAME
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Page/Page column 133-134, (2010/02/14)
Ligands, compositions, metal-ligand complexes and arrays with substituted bridged bis-biaromatic ligands and method of making and using the same, are disclosed that are useful in the catalysis of transformations such as the polymerization of monomers into
Studies on the Oxidation of 1,3-Dithiane and 5,5-Disubstituted Analogues Including X-Ray Crystal Structure, Equilibration Studies and pKa Measurements on Selected Oxides
Aggarwal, Varinder K.,Davies, Ian W.,Franklin, Richard,Maddock, John,Mahon, Mary F.,Molloy, Kieran C.
, p. 2363 - 2368 (2007/10/02)
Oxidation of 1,3-dithiane has been carried out using eight different oxidants under several different reaction conditions.The most favourable conditions for obtaining the required trans-1,3-dithiane 1,3-dioxide were to use either MCPBA in Et2O or NaIO4 in MeOH-H2O.Other 5,5-disubstituted-1,3-dithianes were also prepared and subjected to similar oxidations.For these compounds the best oxidant for obtaining the trans-dioxides was O3.A rationalisation for the stereochemical outcome of the oxidations is presented and required that trans-1,3-dithiane 1,3-dioxide is more stable than cis-1,3-dithiane 1,3-dioxide.This is borne out by equilibration studies of the two diastereoisomeric sulfoxides using N2O4.A rationalisation for the greater stability of the trans compared to the cis isomer is also presented and fits with the pKa values and melting points of the two compounds.
Oxidation of putrescine and cadaverine derivatives by diamine oxidases
Equi, Angela M.,Brown, Alison M.,Cooper, Alan,Her, Surjit K.,Watson, Allan B.,Robins, David J.
, p. 507 - 518 (2007/10/02)
A range of putrescine and cadaverine derivatives has been synthesized and assayed as substrates for the diamine oxidases from pea seedlings and pig kidney. KM and Vmax data are reported, mainly for the pea enzyme. N-Alkylputrescines and C-alkylcadaverines are generally poorer substrates than the parent compounds with up to 4500-fold reduction in Vmax. There is significantly less variation in KM values, indicating that the binding site of the pea enzyme is relatively non-specific and that enzymic specificity lies at the catalytic stage. This suggests that poor substrates might act as convenient, short-lived inhibitors of diamine oxidases.
Synthesis, X-Ray Crystal Structure, Equilibration Studies and Anion Chemistry of trans-1,3-Dithiane 1,3-Dioxide
Aggarwal, Varinder K.,Davies, Ian W.,Franklin, Richard J.,Maddock, John,Mahon, Mary F.,Molloy, Kieran C.
, p. 662 - 664 (2007/10/02)
trans-1,3-Dithiane 1,3-dioxide, prepared by stereoselective oxidation of 1,3-dithiane has been found to be thermodynamically more stable than the cis-isomer by equilibration studies using N2O4 and has been found to undergo highly selective (20:1) aldol ty
