53591-79-0

Basic information

• Product Name: 1-(2',4'-difluoro[1,1'-biphenyl]-4-yl)ethan-1-one
• Synonyms: 1-(2',4'-difluoro[1,1'-biphenyl]-4-yl)ethan-1-one;1-(2',4'-Difluoro-1,1'-biphenyl-4-yl)ethanone;Einecs 258-653-4;1-(2',4'-difluorobiphenyl-4-yl)ethanone
• CAS NO: 53591-79-0
• Molecular Formula: C₁₄H₁₀F₂O
• Molecular Weight: 232.2254064
• EINECS: 258-653-4
• Mol File: 53591-79-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 311.8°Cat760mmHg
• Flash Point: 119.6°C
• Appearance: /
• Density: 1.192g/cm³
• CAS DataBase Reference: 1-(2',4'-difluoro[1,1'-biphenyl]-4-yl)ethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2',4'-difluoro[1,1'-biphenyl]-4-yl)ethan-1-one(53591-79-0)
• EPA Substance Registry System: 1-(2',4'-difluoro[1,1'-biphenyl]-4-yl)ethan-1-one(53591-79-0)

Safety Data

• Hazardous Substances Data: 53591-79-0(Hazardous Substances Data)

Usage

General Description

1-(2',4'-difluoro[1,1'-biphenyl]-4-yl)ethan-1-one is a chemical compound with the molecular formula C14H11F2O. It is a yellow solid that is often used in research and chemical synthesis. 1-(2',4'-difluoro[1,1'-biphenyl]-4-yl)ethan-1-one is a fluorinated derivative of biphenyl, which is a common structural motif in organic chemistry. The presence of fluorine atoms can enhance the compound's stability and reactivity, making it useful in various chemical reactions and processes. The specific properties and uses of 1-(2',4'-difluoro[1,1'-biphenyl]-4-yl)ethan-1-one may vary depending on the intended application, but it is generally valued for its unique structure and potential applications in organic synthesis and materials science.

Upstream product

• 367-25-9 2,4-difluorophenylamine 
• 75-36-5 acetyl chloride 
• 37847-52-2 2,4-difluorobiphenyl 
• 497-19-8 sodium carbonate 
• 99-90-1 para-bromoacetophenone 
• 144025-03-6 2,4-difluorophenylboronic acid 
• 108-24-7 acetic anhydride 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 59089-67-7 4-(2,4-difluorophenyl)phenyl acetate 
• 104941-35-7 (-)-4-(2',4'-difluoro-[1,1'-biphenyl]-4-yl)-2-methyl-4-oxobutanoic acid 

Relevant articles and documents

Synthesis of novel (2E)-1-[4-(2,4-difluorophenyl)phenyl]3-arylprop-2-en-1-ones: Investigation on spectral, antibacterial, molecular docking and theoretical studies

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Water-soluble salen-Pd complex as an efficient catalyst for Suzuki-Miyaura reaction of sterically hindered substrates in pure water

Water-soluble 2N2O-salen ligands and their palladium complexes were synthesized and used as efficient catalysts for the Suzuki-Miyaura reactions in pure water. Notably, the reactions of substrates with sterically demanding ortho substituents (aryl bromides and/or arylboronic acids) proceed smoothly to generate corresponding products with moderate to high yields using 0.5 mol % (salph)Pd (salph=N,N′-bis(4-SO3Na-salicylidene)-1,2-phenylenediamine) as the catalyst. Importantly, the catalytic system has the wide substrate scope and the high tolerance to various functional groups, including cyano, amino, nitro, methoxy, and acetyl. Moreover, the biaryl compounds were also obtained on a multi-gram scale by simple recrystallization with the system in the absence of any organic solvent, surfactant, or phase transfer agent and the catalyst was reused directly for the next cycle. Particularly, this protocol can be applied to synthesize aryl-substituted carbazolyl compounds.

An inexpensive and highly stable palladium(II) complex for room temperature Suzuki coupling reactions under ambient atmosphere

A new air- and moisture-stable Pd(II) complex 3, which is a highly efficient catalyst for Suzuki reaction with low Pd-catalyst loading (0.01%), has been synthesized and characterized by single-crystal X-ray crystallography. The corresponding Suzuki coupling products were obtained in satisfactory to excellent yields at room temperature in aqueous media under ambient atmosphere.