536-88-9

Usage

Uses

Used in Organic Synthesis:
4-Ethyl-2-methylpyridine is used as a reagent in organic synthesis for the production of various chemical compounds. Its unique structure allows it to participate in a wide range of reactions, such as substitution, addition, and condensation, making it a valuable building block for the synthesis of complex organic molecules.
Used in Ruthenium Ion-Catalyzed Oxidation:
In the field of catalysis, 4-ethyl-2-methylpyridine is employed as a ligand in ruthenium ion-catalyzed oxidation reactions. 4-ETHYL-2-METHYLPYRIDINE's ability to coordinate with metal ions, such as ruthenium, enhances the catalytic activity and selectivity of the oxidation process. This application is particularly useful in the pharmaceutical and fine chemicals industries, where selective oxidation reactions are crucial for the synthesis of specific target molecules.

Upstream product

• 109-06-8 α-picoline 
• 3248-28-0 dipropionyl peroxide 
• 75-03-6 ethyl iodide 
• 802294-64-0 propionic acid 
• 108-47-4 2,4-lutidine 
• 74-88-4 methyl iodide 
• 19760-15-7 1-ethyl-2-methylpyridinium iodide 
• 64-17-5 ethanol 
• 2386-64-3 ethylmagnesium chloride 
• 110-86-1 pyridine 
• 7664-41-7 ammonia 

Downstream Products

• 746584-44-1 7-Ethyl-2-phenyl-octahydro-indolizine 
• 180621-68-5 2-(4-Bromo-phenyl)-7-ethyl-indolizine 
• 499-80-9 pyridine-2,4-dicarboxylic acid 

Relevant academic research and scientific papers

Inhibitors of cell proliferation, angiogenesis, fertility, and muscle contraction

The invention concerns inhibitors of cell proliferation, angiogenesis, fertility, and muscle contraction, characterized by formula I wherein, X, Y and Z independently represent C or N; ------ is an optional double bond; n is 0 or 1; R1, R2, and R4 independently represent hydrogen, a chemical bond, C1-10 alkyl; C2-10 alkenyl; C2-10 alkinyl; aryl; aryl-C1-10 alkyl; C3-10 heterocyclyl; C5-10 heteroaryl; halo, CF3; NO2; NHC(O)R*, OR, said alkyl, alkenyl, alkinyl, aryl, arylalkyl, heterocyclyl, or heteroaryl being optionally substituted; R3, R5, and R6 independently represent hydrogen, C1-10alkyl; C2-10 alkenyl; C2-10 alkinyl; aryl; aryl-C1-10alkyl; C3-10 heterocyclyl; C5-10 heteroaryl; halo, CF3; NO2; NHC(O)R*, OR, said alkyl, alkenyl, alkinyl, aryl, heterocyclyl, or heteroaryl being optionally substituted; or R5 and R6 together form a 5- or 6-member aryl, heterocyclyl or heteroaryl group; R is hydrogen or C1-6 alkyl; R* is hydrogen, or C1-6 alkyl, or OH, wherein the optional substituents are preferably selected from the group of one to three OH, C1-6 alkyl, halo, NO2, C1-6 alkoxy, and CF3, or a pharmaceutically acceptable salt thereof.

Process for preparing O-alkyl, O-alkylphosphorochloridothioates

The invention relates to process for the preparation of an O-alkyl, O-alkyl phosphorochloridothioate by 1) reacting A) a thiophosphoryl halide with B) an alcohol, in the presence of C) a tertiary amine acid acceptor and D) a solvent, and 2) reacting the resultant product with a second alcohol, different from the alcohol used in step 1). In the preferred embodiment, the intermediate product is not isolated before reaction with the second alcohol.

Regioselective Addition of Grignard Reagents to 1-Acylpyridinium Salts. A Convenient Method for the Synthesis of 4-Alkyl(aryl)pyridines

The addition of Grignard reagents to 1-acylpyridinium salts afforded 1-acyl-2-alkyl(aryl)-1,2-dihydropyridines and 1-acyl-4-alkyl(aryl)-1,4-dihydropyridines.The regioselectivity of this reaction, 1,2- vs. 1,4-addition, was examined and found to be dependent upon the structures of the Grignard reagent and the 1-acyl group.Pyridine, 2-picoline, and 3-picoline were studied, and in most cases, significant amounts of 1,4-addition occurred.When a catalytic amount of cuprous iodide was present, nearly exclusive 1,4-addition resulted.The crude 1,4-dihydropyridines were aromatized by heating with sulfur to provide 4-substituted pyridines and picolines in good yield and high isomeric purity.