53602-63-4Relevant academic research and scientific papers
CELL SURFACE RECEPTOR BINDING COMPOUNDS AND CONJUGATES
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, (2021/07/17)
The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface receptor, such as a mannose-6-phosphate receptor (M6PR) or a cell surface asialoglycoprotein receptor (ASGPR). The cell surface M6PR or ASGPR binding compounds can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor, e.g., M6PR or ASGPR. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided are methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.
Catechol and Substituted Catechol-Derived Ortho Esters, Models for Protected Active Esters in Peptide Synthesis
Vellaccio, Frank,Phelan, John M.,Trottier, Robert L.,Napier, Thomas W.,Kemp, D.S.
, p. 3087 - 3091 (2007/10/02)
Monoalkyl orthoacetates derived from catechol, 4-nitrocatechol, and tetrabromocatechol have been prepared, and mild conditions (NaI-BF3OEt2) have been found that convert them to the corresponding catechol monoacetates in high yield.Possible applications of ortho esters as protected active esters for peptide synthesis are discussed.
