Synthesis p. 661 - 664 (1986)
Update date:2022-08-04
Topics:
Coutrot, Philippe
Ghribi, Abdellaziz
An efficient and general method for the preparation of 2-oxoalkane phosphonates 2 is described.Diethylphosphono-2-alkanoyl chlorides are used to introduce directly the 2-oxophosphonate 1-substituted synthons on Grignard or cuprate reagents.
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