A Facile and General, One-pot Synthesis of 2-Oxoalkane Phosphonates from Diethylphosphonocarboxylic Acid Chlorides and Organometallic Reagents

DOI: 10.1055/s-1986-31739

Source and publish data:

Synthesis p. 661 - 664 (1986)

Update date:2022-08-04

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Authors:

Coutrot, Philippe

Ghribi, Abdellaziz

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Article abstract of DOI:10.1055/s-1986-31739

An efficient and general method for the preparation of 2-oxoalkane phosphonates 2 is described.Diethylphosphono-2-alkanoyl chlorides are used to introduce directly the 2-oxophosphonate 1-substituted synthons on Grignard or cuprate reagents.

Full text of DOI:10.1055/s-1986-31739

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