109632-31-7

Upstream product

• 762-04-9 phosphonic acid diethyl ester 
• 811-49-4 ethyllithium 
• 53615-31-9 (Chlorocarbonyl-phenyl-methyl)-phosphonic acid diethyl ester 
• 1202-32-0 2-Nitro-1-phenyl-1-butene 
• 1080-32-6 O,O-diethyl benzylphosphonate 
• 38654-91-0 2-(diethoxyphosphino)-2-phenylacetic acid 
• 591-50-4 iodobenzene 
• 1067-73-8 diethyl (2-oxobutyl)phosphonate 

Downstream Products

• 107968-41-2 O,O-diethyl ethyl-1 phenyl-2 ethenyl-1,2 phosphonate 

Relevant academic research and scientific papers

Synthesis of α-arylphosphonates using copper-catalyzed α-arylation and deacylative α-arylation of β-ketophosphonates

Efficient methods for the direct arylation and deacylative arylation of β-ketophosphonates with iodoarenes in presence of a copper(I) or a copper(II) salt as the catalysts have been developed. The corresponding α-arylphosphonates were obtained in high yields. A tentative mechanism for the deacylative arylation reaction was proposed on the basis of the experimental data. Copyright

A general and efficient synthesis of β-ketophosphonates

The acylation of organocuprates or organolithiated reagents with 2-dialkylphosphonoalkanoyl chlorides or dialkylphosphonofluoroacetyl chlorides represents a general and efficient route to β-ketophosphonates.A Horner reaction between the lithiated anions derived from α-fluoro-β-ketophosphonates and aldehydes leads to 2-fluoro-2-enones whereas the lithiated anions derived from γ-acetylenic-β-ketophosphonates afford enynones. β-ketophosphonate / 2-dialkylphosphonoalkanoyl chloride / dialkylphosphonofluoroacetyl chloride / 2-fluoro-2-enone / enynone

A new synthesis of β-keto phosphonate from aryl epoxysulfones and dialkyl hydrogen phosphite

Reaction of α-subtituted arylsulfonyl epoxide with diethyl phosphite sodium salt gave β-keto phosphonate in good yield.

A New Synthesis of 1-Aryl-2-oxoalkylphosphonates from Nitroalkenes and Diethyl Phosphite

Addition of diethyl phosphite to nitroalkenes affords α-phosphoryl nitronates which, on treatment with m-chloroperbenzoic acid, are converted into 1-aryl-2-oxoalkylphosphonates.

A Facile and General, One-pot Synthesis of 2-Oxoalkane Phosphonates from Diethylphosphonocarboxylic Acid Chlorides and Organometallic Reagents

An efficient and general method for the preparation of 2-oxoalkane phosphonates 2 is described.Diethylphosphono-2-alkanoyl chlorides are used to introduce directly the 2-oxophosphonate 1-substituted synthons on Grignard or cuprate reagents.