53620-43-2Relevant articles and documents
Rh-Catalyzed Annulation of ortho-C?H Bonds of 2-Arylimidazoles with 1,4,2-Dioxazol-5-ones toward 5-Arylimidazo[1,2-c]quinazolines
Wu, Xiaopeng,Sun, Song,Xu, Shengbo,Cheng, Jiang
, p. 1111 - 1115 (2018)
A Rh-catalyzed unique and direct approach for constructing a series of 5-arylimidazo[1,2-c]quinazolines in moderate to excellent yields from simple and readily available 2-arylimidazoles and 3-phenyl-1,4,2-dioxazol-5-ones was described. This procedure pro
An expedient synthesis of 5-substituted imidazo[1,2-c]quinazolines
Korshin, Edward E.,Sabirova, Leila A.,Levin, Yakov A.
, p. 3512 - 3522 (2013/01/15)
An efficient three-step synthesis of 5-substituted 2,3-dihydroimidazo[1,2- c]quinazolines and imidazo[1,2-c]quinazolines was elaborated. 2-(2-Aminophenyl)-4,5-dihydro-1H-imidazole, prepared by phosphorus pentasulfide catalyzed condensation of 2-aminobenzonitrile with ethylenediamine, smoothly reacted with aldehydes to give the corresponding 2,3,5,6-tetrahydroimidazo[1,2- c]quinazolines. The CH-NH fragments of the latter were subjected to selective oxidative dehydrogenation with one equivalent of potassium permanganate on silica gel to give 2,3-dihydroimidazo[1,2-c]quinazolines. With two equivalents of potassium permanganate on silica gel, a one-pot exhaustive dehydrogenation to imidazo[1,2-c]quinazolines was accomplished. Georg Thieme Verlag KG · Stuttgart · New York.