5363-29-1

Upstream product

• 88-67-5 2-Iodobenzoic acid 
• 2393-23-9 4-methoxy-benzylamine 
• 123-11-5 4-methoxy-benzaldehyde 
• 118-92-3 anthranilic acid 

Downstream Products

• 169504-53-4 1-(4-ethoxy-benzyl)-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione 
• 1351764-56-1 N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-((4,6-dimethylpyrimidin-2-yl)methoxy)-5-fluoronicotinamide 
• 1351764-55-0 N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-((5-methoxy-2-methylpyrimidin-4-yl)methoxy)nicotinamide 
• 1351764-54-9 N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(pyrimidin-4-ylmethoxy)nicotinamide 
• 1351764-53-8 N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-((2-(pyrimidin-2-yl)propan-2-yl)oxy)nicotinamide 
• 1351764-52-7 N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(1-(pyrimidin-2-yl)ethoxy)nicotinamide 
• 1351764-51-6 (R)-N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(pyrimidin-2-ylmethoxy)nicotinamide 
• 1351764-49-2 (S)-N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(pyrimidin-2-ylmethoxy)nicotinamide 
• 1351764-04-9 N-(5-(2,4-dichloro-6-ethoxyphenyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(pyrimidin-2-ylmethoxy)nicotinamide 
• 1351763-65-9 2-(3-(2H-tetrazol-5-yl)propoxy)-5-chloro-N-(2-oxo-5-(2,4,6-trichlorophenyl)-2,3-dihydro-1-benzo[e][1,4]diazepin-3-yl)benzamide 
• 1351763-82-0 5-fluoro-N-(2-oxo-5-(2,4,6-trichlorophenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-2-(pyridin-4-ylmethoxy)nicotinamide 
• 1351764-50-5 (S)-N-(5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-2-oxo-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-5-fluoro-2-(pyrimidin-2-ylmethoxy)nicotinamide 
• 1351281-45-2 3-amino-5-(2,4-dichloro-6-ethoxyphenyl)-1-(4-methoxybenzyl)-1H-benzo[e][1,4]diazepin-2(3H)-one 
• 1271524-67-4 3-amino-5-(2,4,6-trichloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-one hydrochloride 

Relevant academic research and scientific papers

Ligand compound for copper catalyzed aryl halide coupling reaction, catalytic system and coupling reaction

The invention provides a ligand compound capable of being used for copper catalyzed aryl halide coupling reaction, the ligand compound is a three-class compound containing a 2-(substituted or non-substituted) aminopyridine nitrogen-oxygen group, and the invention also provides a catalytic system for the aryl halide coupling reaction. Thecatalytic system comprises a copper catalyst, a compound containing a 2-(substituted or non-substituted) aminopyridine nitrogen-oxygen group adopted as a ligand, alkali and a solvent, and meanwhile, the invention also provides a system for the aryl halide coupling reaction adopting the catalyst system. The compound containing the 2-(substituted or non-substituted) aminopyridine nitrogen oxygen group can be used as the ligand for the copper catalyzed aryl chloride coupling reaction, and the ligand is stable under a strong alkaline condition and can well maintain catalytic activity when being used for the copper-catalyzed aryl chloride coupling reaction. In addition, the copper catalyst adopting the compound as the ligand can particularly effectively promote coupling of copper catalyzed aryl chloride and various nucleophilic reagents which are difficult to generate under conventional conditions, C-N, C-O and C-S bonds are generated, and numerous useful small molecule compounds are synthesized. Therefore, the aryl halide coupling reaction has a very good large-scale application prospect by adopting the copper catalysis system of the ligand.

Room-temperature Cu-catalyzed: N -arylation of aliphatic amines in neat water

A room-temperature and PTC-free copper-catalyzed N-arylation of aliphatic amines in neat water has been developed. Using a combination of CuI and 6,7-dihydroquinolin-8(5H)-one oxime as the catalyst and KOH as the base, a wide range of aliphatic amines are arylated with various aryl and heteroaryl halides to give the corresponding products in up to 95% yield.

BENZODIAZEPINE COMPOUNDS USEFUL FOR THE TREATMENT OF HEPATITIS C

The invention concerns benzodiazepine derivatives of Formula (I): wherein X, L1, L2, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment or prophylaxis of hepatitis C virus infection.

BENZODIAZEPINE COMPOUNDS USEFUL FOR THE TREATMENT OF HEPATITIS C

The invention concerns benzodiazepine derivatives of Formula (I) wherein A, X, L1, L2, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment or prophylaxis of hepatitis C virus infection.

BENZODIAZEPINE DERIVATIVES FOR TREATING HEPATITIS C INFECTION

The invention concerns benzodiazepine derivatives of Formula (I) wherein W, X, L1, L2, L3, R1, R2, R3, R4, R5, R6 and R7 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment or prophylaxis of hepatitis C virus infection.

2-Pyridinyl β-ketones as new ligands for roomerature CuI-catalysed C-N coupling reactions

2-Pyridinyl β-ketones were identified as new efficient ligands for CuI-catalysed N-arylation of aliphatic amines at room temperature with great selectivity and substrate scope tolerance.