53641-61-5Relevant academic research and scientific papers
Selective binding of metal ions to macromolecules using bifunctional analogs of EDTA
Sundberg,Meares,Goodwin,Diamanti
, p. 1304 - 1307 (1974)
The synthesis of 1 (p benzene diazonium) ethylene diamine tetra acetic acid, the coupling of this compound to proteins, and the binding of radioactive metal ions to the protein bound chelating groups are described. This procedure provides a novel approach to the preparation of radiopharmaceuticals, permitting the separation of synthetic organic chemistry from radiochemistry. Azoproteins labeled with indium 111 are relatively stable in vivo and potentially useful for the detection and localization of tumors. Other chelating agents derived from 1 (p aminophenyl) ethylene diamine tetra acetic acid may permit new applications of a variety of metal ions with useful physical properties to studies of biological systems.
Imidazo(2,1-b)thiazole derivatives, compositions containing same, and method of treating helminthiasis
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, (2008/06/13)
Imidazo[2,1-b]thiazole derivatives are provided having the structure STR1 wherein R1 is hydrogen, lower alkyl or carboxy, and R2 is hydrogen, lower alkyl or phenyl. In addition, a method is provided for treating or inhibiting helmint
1-(P-benzenediazonium)-ethylenediamine tetraacetic acid
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, (2008/06/13)
1-(P-Benzenediazonium)-ethylenediaminetetraacetic acid is described. This material is a chelating agent which forms stable complexes with the ions of heavy metals including those having radioactive properties and also reacts readily and rapidly with biolo
Chelating agents
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, (2008/06/13)
Chelating agents having in addition to their metal sequestering groups a functional group capable of reacting with bio-organic molecules are disclosed, in particular, substituted ethylenedinitrilotetraacetic acids such as 1-p-nitrophenylethylenedinitrilot
