53641-61-5Relevant articles and documents
Selective binding of metal ions to macromolecules using bifunctional analogs of EDTA
Sundberg,Meares,Goodwin,Diamanti
, p. 1304 - 1307 (1974)
The synthesis of 1 (p benzene diazonium) ethylene diamine tetra acetic acid, the coupling of this compound to proteins, and the binding of radioactive metal ions to the protein bound chelating groups are described. This procedure provides a novel approach to the preparation of radiopharmaceuticals, permitting the separation of synthetic organic chemistry from radiochemistry. Azoproteins labeled with indium 111 are relatively stable in vivo and potentially useful for the detection and localization of tumors. Other chelating agents derived from 1 (p aminophenyl) ethylene diamine tetra acetic acid may permit new applications of a variety of metal ions with useful physical properties to studies of biological systems.
1-(P-benzenediazonium)-ethylenediamine tetraacetic acid
-
, (2008/06/13)
1-(P-Benzenediazonium)-ethylenediaminetetraacetic acid is described. This material is a chelating agent which forms stable complexes with the ions of heavy metals including those having radioactive properties and also reacts readily and rapidly with biolo