53670-70-5

Basic information

• Product Name: 2-Acetyl-3-methyl-4-oxopentanoic acid ethyl ester
• Synonyms: 2-Acetyl-3-methyl-4-oxopentanoic acid ethyl ester
• CAS NO: 53670-70-5
• Molecular Formula: C₁₀H₁₆O₄
• Molecular Weight: 200.23
• Mol File: 53670-70-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Acetyl-3-methyl-4-oxopentanoic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetyl-3-methyl-4-oxopentanoic acid ethyl ester(53670-70-5)
• EPA Substance Registry System: 2-Acetyl-3-methyl-4-oxopentanoic acid ethyl ester(53670-70-5)

Safety Data

• Hazardous Substances Data: 53670-70-5(Hazardous Substances Data)

Usage

General Description

2-Acetyl-3-methyl-4-oxopentanoic acid ethyl ester, also known as ethyl acetoacetate, is a chemical compound commonly used as a solvent, flavoring agent, and fragrance ingredient. It is a colorless liquid with a fruity odor, and it is soluble in water and most organic solvents. Ethyl acetoacetate is commonly used in the production of pharmaceuticals, agrochemicals, and dyes, as well as in the synthesis of other organic compounds. It is also used in the manufacturing of artificial flavoring and fragrance agents, as it imparts a pleasant fruity aroma. Additionally, it is a common reagent in organic chemistry reactions, and it is used as a building block in the synthesis of many other important chemicals.

Upstream product

• 141-97-9 ethyl acetoacetate 
• 814-75-5 3-bromo-butanone 
• 4091-39-8 3-chloro-2-butanone 
• 1007476-32-5 sodium ethyl acetylacetate enolate 

Downstream Products

• 137303-89-0 4,5-diacetyl-1,2,4-trimethyl-cyclohexene 
• 97204-34-7 3-methyl-hex-3-ene-2,5-dione 
• 1795-05-7 2,4,5-trimethylthiophene 
• 4437-50-7 3-methyl-hexane-2,5-dione 
• 2199-54-4 2,4,5-trimethyl-3-ethoxycarbonylpyrrole 
• 931-22-6 3,5-dimethyl-2-cyclopenten-1-one 
• 28730-32-7 2,4,5-trimethylfuran-3-carboxylic acid 
• 10504-04-8 2,3,5-trimethylfuran 

Relevant articles and documents

Acylaminoimidazole derivative and use thereof

The invention belongs to the technical field of medicines and relates to an acylaminoimidazole derivative shown in the general formula I and its stereisomer and pharmaceutical acceptable salt, hydrate, solvate or prodrug. In the formula I, substituents R, R1, Ar, M and X are defined in the specification. The invention also relates to a method for preparing the compound shown in the formula I, a medicinal composition containing the compound and a use of the compound and the medicinal composition in preparation of drugs for treating and/or preventing cancers and other skin proliferative diseases. An antifungal experiment proves that the compound has strong resistance to shallow and deep fungi and can be used for preparation of an antibacterial drug.

THE SYNTHESIS AND CHEMISTRY OF AZOLENINES. PART 18. PREPARATION OF 3-ETHOXYCARBONYL-3H-PYRROLES VIA THE PAAL-KNORR REACTION, AND SIGMATROPIC REARRANGEMENTS INVOLVING COMPETITIVE ESTER MIGRATIONS TO C-2, C-4 AND N.

3H-Pyrrole-3-carboxylic esters (4) have been prepared, in some cases together with isomers (5) and (6) having exocyclic double bonds, by cyclization of suitably substituted 2-ethoxycarbonyl-1,4-diketones (1) with liquid ammonia, followed by dehydration of the isolable 2-hydroxy-3,4-dihydro-2H-pyrrole intermediates (2) and (3) with aluminia in boiling solvents.Prolonged heating in toluene or p-xylene converts the 3H-pyrroles (4) quantitatively into isomeric 4-esters (11) and N-esters (13) of 1H-pyrroles via competitive sigmatropic rearrangements.Isolable intermediate 2H-pyrrole-2-carboxylic esters (12) are converted similarly into the same products, under the same conditions.Detection of 3H-pyrroles (4) as intermediates in the latter reaction demonstrates for the first time the reversibility of the thermal 2H-pyrrole to 3H-pyrrole interconversion.

Polyene compounds

Novel 9-substituted or unsubstituted thienyl-3,7-dimethyl-nona-2,4,6,8-tetraene derivatives, useful as antitumor agents as well as processes for their preparation and novel intermediates are disclosed.