4437-50-7Relevant academic research and scientific papers
SYNTHESIS OF 1,4-DICARBONYL COMPOUNDS BY THE CERIC AMMONIUM NITRATE PROMOTED REACTION OF KETONES WITH VINYL AND ISOPROPENYL ACETATE
Baciocchi, Enrico,Civitarese, Giampiero,Ruzziconi, Renzo
, p. 5357 - 5360 (1987)
1,4-Diketones and 4-ketoaldehydes dimethylacetals can be prepared in good yields (65-82percent) by the cerium(IV) ammonium nitrate promoted reaction of ketones with isopropenyl acetate and vinyl acetate, respectively.
SYNTHESIS OF UNSYMMETRICAL 1,4-DIKETONES BY THE CERIC AMMONIUM NITRATE PROMOTED CROSS-COUPLING OF TRIMETHYLSILYL ENOL ETHERS
Baciocchi, Enrico,Casu, Angela,Ruzziconi, Renzo
, p. 3707 - 3710 (1989)
Unsymmetrical 1,4-diketones are prepared in good yields (60-80percent) by cerium (IV) ammonium nitrate oxidative cross-coupling between 1,2-disubstituted and 1-substituted trimethylsilyl enol ethers.
Discovery and structure-activity relationships of pyrrolone antimalarials
Murugesan, Dinakaran,Mital, Alka,Kaiser, Marcel,Shackleford, David M.,Morizzi, Julia,Katneni, Kasiram,Campbell, Michael,Hudson, Alan,Charman, Susan A.,Yeates, Clive,Gilbert, Ian H.
supporting information, p. 2975 - 2990 (2013/05/23)
In the pursuit of new antimalarial leads, a phenotypic screening of various commercially sourced compound libraries was undertaken by the World Health Organisation Programme for Research and Training in Tropical Diseases (WHO-TDR). We report here the detailed characterization of one of the hits from this process, TDR32750 (8a), which showed potent activity against Plasmodium falciparum K1 (EC50 ～ 9 nM), good selectivity (>2000-fold) compared to a mammalian cell line (L6), and significant activity against a rodent model of malaria when administered intraperitoneally. Structure-activity relationship studies have indicated ways in which the molecule could be optimized. This compound represents an exciting start point for a drug discovery program for the development of a novel antimalarial.
(Phosphine)carbonylnitrosylacylcobaltate Complexes as Acyl Transfer Reagents. Acylation of Allylic Halides, Conjugated Enones, and Quinones
Hegedus, Louis S.,Perry, Robert J.
, p. 4955 - 4960 (2007/10/02)
The complex Co(NO)(CO)2(PPh3) is an air stable, easily handled crystalline solid, prepared from Co2(CO)8, sodium nitrite, and triphenylphosphine without isolation of the volatile intermediate Co(NO)(CO)3.Treatment of this complex with organolithium reagents at -40 deg C generated unstable acylate complexes - which readily transferred the acyl group to allylic halides to produce β,γ-unsaturated ketones, to conjugated ketones to produce 1,4-dicarbonyl compounds, and to quinones to form 4-acylcyclohexadienones.
PALLADIUM OR RUTHENIUM CATALYZED REACTION OF Α-HALO KETONES WITH TRIBUTYLTIN ENOLATES: PREPARATION OF UNSYMMETRICAL 1,4-DIKETONES
Kosugi, Masanori,Takano, Izumi,Sakurai, Motoi,Sano, Hiroshi,Migita, Toshihiko
, p. 1221 - 1224 (2007/10/02)
Palladium or ruthenium catalyzed cross-coupling of α-halo ketones with tributyltin enolates gave unsymmetrical 1,4-diketones.The method was applied to the dihydrojasmone synthesis.
The Synthesis of 1,4-Diketones via Fluoride-catalysed Michael Addition and Supported-permanganate-promoted Nef Transformation
Clark, James H.,Cork, David G.,Gibbs, Hugh W.
, p. 2253 - 2258 (2007/10/02)
A versatile synthetic route for the preparation of 1,4-diketones from simple starting materials is described and applied to the preparation of a wide range of diketones.The two most important steps in the reaction are the fluoride ion-catalysed Michael addition of a nitroalkane to a vinyl ketone and the subsequent transformation of the nitro ketone to the diketone using supported permanganate as the oxidant.The interaction of F- with nitroethane has been studied and a number of sources of F- have been tested in the Michael addition reaction.Potassium fluoride supported on alumina and potassium permanganate supported on silica gel are remarkably efficient reagents for the Michael addition and Nef transformation stages, respectively, although it is important to determine the best reagent loadings and drying conditions for maximum reaction efficiency to be achieved.
Synthesis of 1,4-Diketones by Fluoride-catalysed Michael Addition and Supported Permanganate Oxidation
Clark, James H.,Cork, David G.
, p. 635 - 636 (2007/10/02)
A wide variety of 1,4-diketones may be prepared from simple starting materials by using fluoride ion-catalysed Michael additions and silica gel-supported permanganate-promoted Nef transformations.
Polyene compounds
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, (2008/06/13)
Novel 9-substituted or unsubstituted thienyl-3,7-dimethyl-nona-2,4,6,8-tetraene derivatives, useful as antitumor agents as well as processes for their preparation and novel intermediates are disclosed.
