536760-32-4

Basic information

• Product Name: 1-BENZYL-4-IODO-IMIDAZOLE
• Synonyms: 1-BENZYL-4-IODO-IMIDAZOLE;1H-IMIDAZOLE, 4-IODO-1-(PHENYLMETHYL)-;4-IODO-1-BENZYLIMIDAZOLE;4-iodo-1-(phenylmethyl)-1H-imidazole;1-benzyl-4-iodo-1H-iMidazole
• CAS NO: 536760-32-4
• Molecular Formula: C₁₀H₉IN₂
• Molecular Weight: 284.1
• Mol File: 536760-32-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 99-100 °C
• Boiling Point: 388.4°C at 760 mmHg
• Flash Point: 188.7°C
• Appearance: /
• Density: 1.67g/cm³
• Vapor Pressure: 6.86E-06mmHg at 25°C
• Refractive Index: 1.667
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.24±0.61(Predicted)
• CAS DataBase Reference: 1-BENZYL-4-IODO-IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BENZYL-4-IODO-IMIDAZOLE(536760-32-4)
• EPA Substance Registry System: 1-BENZYL-4-IODO-IMIDAZOLE(536760-32-4)

Safety Data

• Hazardous Substances Data: 536760-32-4(Hazardous Substances Data)

Usage

General Description

1-Benzyl-4-Iodo-Imidazole is a chemical compound commonly used in the field of organic chemistry. Its systematic name is 1-(phenylmethyl)-4-iodo-1H-imidazole. Its chemical formula is C10H9IN2 and its molecular weight is 290.09 g/mol. The compound is still under study by chemists for its precise physical and chemical properties, but in general, imidazole derivatives are known for their significance in medicinal chemistry due to their presence in key biological compounds. The iodine atom and benzyl group in the structure make it potentially useful in various chemical reactions.

InChI:InChI=1/C10H9IN2/c11-10-7-13(8-12-10)6-9-4-2-1-3-5-9/h1-5,7-8H,6H2

Upstream product

• 100-44-7 benzyl chloride 
• 536760-31-3 1-benzyl-4,5-diiodo-1H-imidazole 
• 100-39-0 benzyl bromide 
• 4238-71-5 1-benzylimidazole 
• 71759-89-2 4-iodoimidazole 

Downstream Products

• 86803-30-7 1-benzyl-4-ethenyl-1H-imidazole 
• 941287-16-7 2-azido-1-benzyl-4-ethenyl-1H-imidazole 
• 941287-19-0 2-amino-1-benzyl-4-ethenyl-1H-imidazole 
• 941287-20-3 1-benzyl-2-[(tert-butoxycarbonyl)amino]-4-ethenyl-1H-imidazole 
• 1027421-00-6 1-benzyl-2-(N-phthaloylamino)-4-ethenyl-1H-imidazole 
• 881211-45-6 [3-(2-azido-1-benzyl-1H-imidazol-4-yl)-prop-2-ynyl]-carbamic acid tert-butyl ester 

Relevant articles and documents

4—(1H— IMIDAZOL— 5— YL) -1H-PYRROLO [2, 3-B] PYRIDINES FOR USE IN THE TREATMENT OF LEUKAEMIAS, LYMPHOMAS AND SOLID TUMORS

The present invention relates to novel 4-(1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine compounds which are useful in the treatment of lymphomas, leukaemias, and solid tumors.

NOVEL TETRAHYDROPYRIDOPYRIMIDINES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The present invention provides novel compounds having the general formula: wherein R1, R2 and R3 are as described herein, compositions including the compounds and methods of using the compounds.

Preparation and diels-alder chemistry of 4-vinylimidazoles

(Chemical Equation Presented) Various 4-vinylimidazole derivatives have been prepared from the corresponding 4-iodoimidazoles or from urocanic acid. Several methods for the elaboration of these vinylimidazoles and their Diels-Alder reactions are reported. All of the vinylimidazoles prepared in the course of this study react with N-phenylmaleimide quite readily with mild thermal activation providing a single cycloadduct, in most cases the initial, nonaromatic adduct. With more electron rich substrates, there is a tendency for these initial cycloadducts to undergo aromatization, ene reaction, and oxidation although this can be circumvented to a large extent by the choice of reaction conditions. Limited reactions were observed with other dienophiles, providing the expected cycloadducts in most cases, although an abnormal adduct was obtained in one case with dimethyl acetylene dicarboxylate. These substrates also participate in regioselective Diels-Alder reactions with monoactivated dienophiles, but require fairly forcing conditions, thus only providing the aromatized cycloadducts in modest yields. An investigation of substituent effects at the 2-position of the imidazole moiety was undertaken, in which electron-donating and weakly electron-withdrawing substituents are tolerated. In addition, several substrates with terminally substituted vinyl moieties have been investigated.