625-08-1Relevant articles and documents
Preparation method of calcium [beta]-hydroxy-[beta]-methylbutyrate
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Paragraph 0025; 0027; 0030-0054, (2020/07/24)
The invention discloses a preparation method of calcium [beta]-hydroxy-[beta]-methylbutyrate, which comprises the following steps: S1) condensation reaction: adding ethyl chloroacetate and acetone into a solvent, and dropwisely adding an alkali solution to obtain a 3, 3-dimethyl oxide-2-carboxylic acid ethyl ester solution; S2) hydrolysis reaction: adding an aqueous solution of alkali into a solution of 3, 3-dimethyl oxide-2-carboxylic acid ethyl ester, and performing acidifying to obtain 3, 3-dimethyl oxide-2-carboxylic acid; S3) hydrogenation reaction: adding 3, 3-dimethyl oxide-2-carboxylicacid into the Pt/C alcohol system, and performing hydrogenation to obtain [beta]-hydroxy-[beta]-methylbutyrate acid; and S4) salifying reaction: adding water, calcium salt and a catalyst into the organic solution of [beta]-hydroxy-[beta]-methylbutyrate acid to react, and performing filtering, pulping and drying to prepare the finished product calcium [beta]-hydroxy-[beta]-methylbutyrate. The preparation method disclosed by the invention is simple in process, easy to operate, environment-friendly, free of pollution, safe in calcium reagent, free of residue, low in cost, safe to operate, easy for industrial large-scale production, high in conversion rate and good in product quality.
PROCESS FOR PREPARING 3-HYDROXY-3-METHYLBUTYRATE (HMB) AND SALTS THEREOF
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Page/Page column 8-9, (2020/10/31)
The present invention pertains to a process for preparing 3-hydroxy-3-methylbutyrate (HMB) or a salt thereof, the method comprising (a) reacting isobutylene oxide with cyanide in order to obtain 3- hydroxy-3-methylbutyronitrile, and (b) hydrolyzing the 3-hydroxy-3-methylbutyronitrile obtained in step (a) in order to obtain HMB, wherein hydrolysis step (b) is performed using either at least one nitrilase enzyme or, alternatively, using a combination of enzymes, said combination comprising at least one nitrile hydratase and at least one amidase.
Substituted heteroaryl compounds and compositions and uses thereof (by machine translation)
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Paragraph 1815; 1817; 1818, (2019/06/07)
The invention discloses substituted heteroaryl compounds and compositions thereof and their use. The compounds of formula (I) compound or type shown in (I) a compound represented by stereo isomers, tautomers, nitrogen oxide, solvate, metabolite, pharmaceutically acceptable salt or its prodrug. The invention also provides a pharmaceutical composition, the compounds and pharmaceutical compositions can be regulated protein kinase, particularly Aurora kinase and JAK kinase activity, for the prevention, treatment, treatment and reduce protein kinase, in particular JAK kinase activity mediated diseases or disorders. (by machine translation)