537030-26-5

Upstream product

• 532-20-7 D-arabinofuranose 
• 1567688-03-2 (2R,3R,4R,5R)-tert-butyl 3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-5-(2,3-dihydroxypropyl)pyrrolidine-1-carboxylate 
• 1567688-00-9 (2R,3R,4R,5R)-tert-butyl 2-allyl-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)pyrrolidine-1-carboxylate 
• 537030-18-5 Methanesulfonic acid (1S,2S,3R)-2,3-bis-benzyloxy-1-benzyloxymethyl-4-(tetrahydro-pyran-2-yloxyimino)-butyl ester 
• 537030-24-3 (2R,3aR,4R,5R,6R)-4,5-bis(benzyloxy)-6-[(benzyloxy)methyl]-N,N-dimethylhexahydropyrrolo[1,2-b]isoxazole-2-carboxamide 
• 537030-17-4 (2R,3R,4S)-2,3,5-Tris-benzyloxy-4-hydroxy-pentanal O-(tetrahydro-pyran-2-yl)-oxime 
• 16838-89-4 2,3,5-tri-O-benzyl-L-xylofuranose 
• 100-44-7 benzyl chloride 
• 41546-31-0 L-xylose 
• 631915-22-5 (1E)-2,3,5-tri-O-benzyl-4-deoxy-4-iodo-L-xylose O-[(tert-butyl)triphenylsilyl]oxime 
• 631915-23-6 (2R,3aR,4R,5R,6R)-hexahydro-4,5-bis(phenylmethoxy)-6-[(phenylmethoxy)methyl]pyrrolo[1,2-b]isoxazole-2-methanol 
• 537030-20-9 (2R,3R,4R)-2,3,5-tris(benzyloxy)-4-hydroxypentanal O-(tertbutyldiphenylsilyl)oxime 
• 537030-19-6 (2R,3R,4R)-3,4-bis(benzyloxy)-2-((benzyloxy)methyl)-3,4-dihydro-2H-pyrrole 1-oxide 
• 620946-66-9 (E/Z)-2,3,5-tri-O-benzyl-D-arabinose-oxime 

Relevant academic research and scientific papers

Synthesis and inhibition study of bicyclic iminosugar-based alkaloids, scaffolds, and libraries towards glucosidase

A small library of bicyclic iminosugar-based alkaloids and scaffolds possessing a polyhydroxylated pyrrolidine and a varied ring skeleton have been synthesized. Through rapid diversification of the scaffold via an amide coupling with random carboxylic acids, structurally diverse bicyclic iminosugar-based libraries were prepared with substituent diversity, core diversity, and configurational diversity. This discovery process allowed us to efficiently sieve out potent and specific glycosidase inhibitors, and a bicyclic, conformationally restricted iminosugar was demonstrated to be more potent than the monocyclic ones in this study. The most potent and selective inhibitor discovered was found to have a Ki value of 71 nM against α-glucosidase.

6-Azido hyacinthacine A2 gives a straightforward access to the first multivalent pyrrolizidine architectures

The synthesis of the first multivalent pyrrolizidine iminosugars is reported. The key azido intermediates 4 and 31 were prepared after suitable synthetic elaboration of the cycloadduct obtained from 1,3-dipolar cycloaddition of d-arabinose derived nitrone

Synthesis, biological evaluation and docking studies of casuarine analogues: Effects of structural modifications at ring B on inhibitory activity towards glucoamylase

We report the total synthesis of a series of pyrrolizidine analogues of casuarine (1) and their 6-O-α-glucoside derivatives. The synthetic strategy is based on a totally regio- and stereoselective 1,3-dipolar cycloaddition of suitably substitutedalkenes a

Total syntheses of hyacinthacine A2 and 7-deoxycasuarine by cycloaddition to a carbohydrate derived nitrone

Practical syntheses of nitrone 8 by two different approaches from sugars are reported. Its use as a versatile intermediate in highly selective 1,3-dipolar cycloaddition reactions constitutes the key step for novel total syntheses of hyacinthacine A2

Synthesis and glycosidase inhibitory activity of 7-deoxycasuarine

Reaction of 1,4-anhydro-2,3,5-tri-O-benzyl-1-deoxy-1-imino-D-arabinitol N-oxide (8) with allyl alcohol produced a 3.6:1 mixture of the two pyrrolo[1,2-b]isoxazole derivatives 13 and 14. The major adduct 13 was converted to 7-deoxycasuarine (7), a potent,