537036-14-9

Basic information

• Product Name: (7R)-6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one
• CAS NO: 537036-14-9
• Molecular Formula: C₁₁H₇ClN₄O₂
• Molecular Weight: 262.6519
• Mol File: 537036-14-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 525.2°C at 760 mmHg
• Flash Point: 271.5°C
• Density: 1.653g/cm³
• Vapor Pressure: 7.35E-12mmHg at 25°C
• Refractive Index: 1.719
• CAS DataBase Reference: (7R)-6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: (7R)-6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one(537036-14-9)
• EPA Substance Registry System: (7R)-6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one(537036-14-9)

Safety Data

• Hazardous Substances Data: 537036-14-9(Hazardous Substances Data)

Upstream product

• 75-36-5 acetyl chloride 
• 43200-81-3 6-(5-chloropyridin-2-yl)-7-hydroxy-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one 
• 141-75-3 butyryl chloride 
• 138729-47-2 eszopiclone 
• 5130-24-5 Vinyl chloroformate 
• 627-11-2 2-Chloroethyl chloroformate 
• 22128-62-7 carbonochloridic acid, chloromethyl ester 
• 43200-83-5 3-((5-chloropyridin-2-yl)carbamoyl)pyrazine-2-carboxylic acid 
• 43200-80-2 zopiclon 
• 1072-98-6 5-chloro-2-pyridylamine 
• 4744-50-7 2,3-pyrazinedicarboxylic anhydride 
• 508169-18-4 (+/-)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one 
• 43200-82-4 6-(5-chloro-2-pyridyl)-5,7-dioxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazine 
• 144025-94-5 (R)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate D-(+)-O,O'-dibenzoyltartaric acid salt 

Downstream Products

• 508169-20-8 (S)-(+)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one 
• 508169-19-5 (S)-(+)-7-(2-chloroethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one 
• 144025-94-5 (R)-6-(5-chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4b]pyrazin-5-yl 4-methylpiperazine-1-carboxylate D-(+)-O,O'-dibenzoyltartaric acid salt 
• 144025-93-4 eszopiclone dibenzoyl-D-tartrate 
• 148891-53-6 6-(5-chloropyridin-2-yl)-6,7-dihydropyrrolo[3,4-b]pyrazin-5-one 
• 508169-18-4 (+/-)-7-(2-chloromethyloxycarbonyloxy)-6-(5-chloropyridin-2-yl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one 

Relevant articles and documents

Preparation method of zopiclone intermediate

The invention provides a preparation method of zopiclone. According to the method, anhydride is used as a reaction solvent, pyrazine-2,3-dianhydride and 2-amino-5-chloropyridine are synthesized into 6-(5-chloro-2-pyridyl)-5,7-dioxo-6,7-dihydro-5H-pyrrolo(3,4-b)pyrazine in one step, so that the process is simplified, the obtained product is high in yield and purity, production conditions and environment friendliness are achieved, and the method is suitable for industrial production.

Preparation method for pyrrolo-pyrazine

The invention discloses a preparation method for pyrrolo-pyrazine. The preparation method comprises the following steps that 1, levo-zopiclone (I) is dissolved into organic solvent, the pH is regulated to 8-10, and heating reflux is performed; 2, water is added, stirring is performed, standing is performed for layering, and a water layer is separated out; 3, the step 2 is repeated; 4, a drying agent is added in an organic layer for drying, filtering is performed, and filtrate is concentrated under reduced pressure until the filtrate is dried into a compound (II); 5, the compound (II) is dissolved into the organic solvent, an oxidizing agent is added, heating reflux oxidation is performed, filtering is performed, filtrate is concentrated under reduced pressure, cooling and crystallizing are performed, filtering is performed, and solids are dried to obtain the pyrrolo-pyrazine (III). According to the method, the by-product levo-zopiclone generated in eszopiclone production can be taken as the raw material to generate the pyrrolo-pyrazine (III) through reacting, the pyrrolo-pyrazine (III) generates zopiclone according to a conventional technique, waste utilization is maximized on the premise that the quality is guaranteed, and discharge of three wastes is greatly reduced.

Preparation method of pyrazine hydroxyl pyrrolidone compound

The present invention discloses a preparation method of a pyrazine hydroxyl pyrrolidone compound. The preparation method comprises the steps of: (a) adjusting the pH value of water to higher than 7 with inorganic base to obtain an aqueous solution of inorganic base, or adjusting the pH value of a water-containing organic solvent to higher than 7 with inorganic base to obtain an inorganic base water-containing organic solvent solution, and dissolving potassium borohydride or sodium borohydride; and (2) dissolving the raw materials in a solvent in a container to obtain a raw material solution, controlling the reaction temperature at 11-15 DEG C, adding a potassium borohydride solution or a sodium borohydride solution, and reacting to obtain the pyrazine hydroxyl pyrrolidone compound. According to the method, potassium borohydride or sodium borohydride is added in the form of solution into the reaction system, and the control of feed rate by temperature indication avoids instantaneous release of excessive hydrogen. The method solves in the problem of instantaneous release of excessive hydrogen due to difficulty in controlling a single dosage in the traditional methods, and has the characteristics of simpleness, safe and reliable production, high yield and good product quality.