53755-58-1

Usage

Uses

Used in Pharmaceutical Industry:
Drupanin is used as a potential therapeutic agent for treating various health conditions due to its antifungal, antimicrobial, and antioxidant properties.
Used in Anticancer Applications:
Drupanin is being studied for its potential use as an anticancer agent, as it may help in the treatment of various types of cancer.
Used in Anti-inflammatory Applications:
Drupanin is used as an anti-inflammatory agent to help reduce inflammation and alleviate related symptoms.
Used in Antimicrobial Applications:
Drupanin is used as an antimicrobial agent to combat infections caused by bacteria and other microorganisms.
Used in Oxidative Stress Protection:
Drupanin is used to protect cells from oxidative damage, which can contribute to various health issues and the aging process.
Further research is necessary to fully understand the therapeutic potential of drupanin and its possible applications in medicine.

InChI:InChI=1/C14H16O3/c1-10(2)3-6-12-9-11(4-7-13(12)15)5-8-14(16)17/h3-5,7-9,15H,6H2,1-2H3,(H,16,17)/b8-5+

Upstream product

• 72704-01-9 (E)-methyl 3-[4-Hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]acrylate 
• 151071-02-2 methyl (E)-3-[4-(acetyloxy)-3-(3-methyl-2-butenyl)phenyl]-2-propenoate 
• 540-38-5 p-Iodophenol 
• 151071-03-3 4-iodo-2-(3-methylbut-2-en-1-yl)phenol 
• 1208233-14-0 tert-butyl (E)-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]acrylate 
• 3943-97-3 methyl 4-hydroxycinnamate 
• 870-63-3 prenyl bromide 
• 7400-08-0 p-Coumaric Acid 
• 151071-04-4 4-iodo-2-(3-methylbut-2-en-1-yl)phenyl acetate 

Downstream Products

• 1208233-09-3 drupanin phenethyl ester 
• 72704-01-9 (E)-methyl 3-[4-Hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]acrylate 

Relevant academic research and scientific papers

Palladium-Catalyzed Directed para C?H Functionalization of Phenols

Various practical methods for the selective C?H functionalization of the ortho and recently also of the meta position of an arene have already been developed. Following our recent development of the directing-group-assisted para C?H functionalization of toluene derivatives, we herein report the first remote para C?H functionalization of phenol derivatives by using a recyclable silicon-containing biphenyl-based template. The effectiveness of this strategy was illustrated with different synthetic elaborations and by the synthesis of various phenol-based natural products.

Inhibitory activity of Brazilian green propolis components and their derivatives on the release of cys-leukotrienes

The effects of Brazilian green propolis ethanol extract on Cry j1-induced cys-leukotrienes and histamine release from peripheral leukocytes of patients with allergic rhinitis were investigated. One of the key mechanisms for the anti-allergic properties of the extract was revealed to be the suppression of cys-LTs release. Furthermore, a series of propolis components and their phenethyl esters were synthesized and evaluated as inhibitors of cys-LTs release. Artepillin C, baccharin, and kaempferide were the major active components of the ethanol extract. The inhibitory activity of artepillin C phenethyl ester was comparable to that of existing LT synthesis inhibitors. Crown Copyright

Artepillin C isoprenomics: Design and synthesis of artepillin C isoprene analogues as lipid peroxidation inhibitor having low mitochondrial toxicity

We designed and synthesized isoprene analogues of artepillin C, a major component of Brazilian propolis, and investigated the inhibitory activity on lipid peroxidation of rat liver mitochondria (RLM) and RLM toxicity based on isoprenomics. We succeeded in

Structure-antimutagenic activity relationship study of plicatin B

A systematic structure-activity relationship study of plicatin B (1), an antimutagenic constituent of Psoralea juncea, was undertaken with a view toward elucidating its chemical mode of action and possibly optimizing its antimutagenic activity during the process. Compound 1 and its related analogues were examined for their antimutagenic activity against mutations induced by ethyl methanesulfonate, a direct acting mutagen and alkylating agent, in Salmonella typhimurium strain TA100, utilizing the modified Ames test protocol. The dihydro analogue 3 resulting from saturation of the conjugated alkene double bond of 1 was found to exhibit reduced cytotoxicity and enhanced efficacy relative to the parent compound. This result serves preliminarily to exclude a Michael acceptor role of the α,β-unsaturated carbonyl moiety in connection with its antimutagenic activity.

Synthesis of Phenolic Natural Products Using Palladium Catalyzed Coupling Reactions

Derivatives of 2,4-diiodophenol are shown to undergo palladium catalyzed carbonylation and alkyne coupling reactions in excellent to moderate yield and high regioselectivity.The scope of these reactions is explored.Palladium catalyzed reactions are employ

Isolation and Identification of Antimicrobal Compounds in Brazilian Propolis

Three distinct antimicrobal compounds were isolated from Brazilian propolis.These compounds were identified as 3,5-diprenyl-4-hydroxycinnamic acid(1), 3-prenyl-4-dihydrocinnamoloxycinnamic acid (2), and 2,2-dimethyl-6-carboxyethenyl-2H-1-benzopyran (3).The respective antimicrobal activity, expressed as MIC in μg/ml, 1-3 against Bacillus cereus was 15.6, 31.3, and 125; that against Enterobacter aerogenes was 31.3, 62.5, and 125; and that against Arthroderma benhamiae was 15.6, 250, and 62.5.Compound 1 is likely to be one of the major antimicrobal compounds in Brazilian propolis.

PLICATIN B, THE ANTIMICROBIAL PRINCIPLE OF PSORALEA JUNCEA

The major antimicrobial agent present in extracts of the leaves and stems of Psoralea juncea is identified as methyl 3--2-(E)-propenoate (plicatin B) by spectroscopic and chemical correlations.Key Word Index - Psora