537710-06-8Relevant articles and documents
In Vivo Gold Complex Catalysis within Live Mice
Tsubokura, Kazuki,Vong, Kenward K. H.,Pradipta, Ambara R.,Ogura, Akihiro,Urano, Sayaka,Tahara, Tsuyoshi,Nozaki, Satoshi,Onoe, Hirotaka,Nakao, Yoichi,Sibgatullina, Regina,Kurbangalieva, Almira,Watanabe, Yasuyoshi,Tanaka, Katsunori
, p. 3579 - 3584 (2017)
Metal complex catalysis within biological systems is largely limited to cell and bacterial systems. In this work, a glycoalbumin–AuIII complex was designed and developed that enables organ-specific, localized propargyl ester amidation with nearby proteins within live mice. The targeted reactivity can be imaged through the use of Cy7.5- and TAMRA-linked propargyl ester based fluorescent probes. This targeting system could enable the exploitation of other metal catalysis strategies for biomedical and clinical applications.
Synthesis and Analysis of Natural-Product-Like Macrocycles by Tandem Oxidation/Oxa-Conjugate Addition Reactions
Lee, Hyunji,Sylvester, Kayla,Derbyshire, Emily R.,Hong, Jiyong
supporting information, p. 6500 - 6504 (2019/04/30)
As traditional small-molecule drug discovery programs focus on a relatively narrow range of chemical space, most human proteins are viewed as unreachable targets. Consequently, there is a strong interest in expanding the chemical space in drug discovery b
Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters
Vong, Kenward K. H.,Tsubokura, Kazuki,Nakao, Yoichi,Tanei, Tomonori,Noguchi, Shinzaburo,Kitazume, Shinobu,Taniguchi, Naoyuki,Tanaka, Katsunori
supporting information, p. 8403 - 8406 (2017/08/02)
Rapidly growing cancer cells have increased levels of intracellular polyamines compared to normal, healthy tissues. Based on the selective reactivity of glycine propargyl esters, probes were synthesized that show evidence for selective polyamine reactivit
