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538-71-6

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538-71-6 Usage

Description

Domiphen is a quaternary ammonium compound and cationic surfactant with antimicrobial activity. It is active against A. viscosus, A. naeslundii, S. mutans, E. coli, and L. monocytogenes bacteria and inhibits C. neoformans yeast growth and spore germination. It also inhibits the human-ether-a-go-go-related gene (hERG) channel (IC50 = 1.5 μM in a whole-cell patch-clamp assay). Formulations containing domiphen have been used as antiseptics, disinfectants, and biocides in industrial, agricultural, veterinary, and clinical applications.

Originator

Bradosol,Ciba,US,1958

Uses

Domiphen bromide is employed as a phase transfer catalyst in synthetic chemistry. It is used as a quaternary ammonium cation with cationic surfactant properties. Further, it is used as an antiseptic and an active pharmaceutical ingredient.

Manufacturing Process

7 parts of β-phenoxyethyl-dimethylamine are heated for 2 hours on the boiling water-bath with 11 parts of dodecyl bromide. A good yield of β-phenoxy-ethyldimethyl-dodecyl-ammonium bromide is obtained which, after recrystallization from acetone, melts at 112°C. It is a white crystalline powder which dissolves easily in water to give a neutral reaction.

Safety Profile

Poison by intraperitoneal and intravenous routes. hfutauon data reported. When heated to decomposiuon it emits very toxic fumes of NOx, NH3, and Br-. See also BROMIDES.

Check Digit Verification of cas no

The CAS Registry Mumber 538-71-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 8 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 538-71:
(5*5)+(4*3)+(3*8)+(2*7)+(1*1)=76
76 % 10 = 6
So 538-71-6 is a valid CAS Registry Number.
InChI:InChI=1/C22H40NO.BrH/c1-4-5-6-7-8-9-10-11-12-16-19-23(2,3)20-21-24-22-17-14-13-15-18-22;/h13-15,17-18H,4-12,16,19-21H2,1-3H3;1H/q+1;/p-1

538-71-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Alfa Aesar

  • (L12930)  Domiphen bromide, 97%   

  • 538-71-6

  • 25g

  • 314.0CNY

  • Detail
  • Alfa Aesar

  • (L12930)  Domiphen bromide, 97%   

  • 538-71-6

  • 100g

  • 896.0CNY

  • Detail
  • Aldrich

  • (247480)  Domiphenbromide  97%

  • 538-71-6

  • 247480-25G

  • 468.00CNY

  • Detail

538-71-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name Domiphen bromide

1.2 Other means of identification

Product number -
Other names Dodecyldimethyl-2-Phenoxyethylammonium Bromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:538-71-6 SDS

538-71-6Synthetic route

dimethyl(2-phenoxyethyl)amine
13468-02-5

dimethyl(2-phenoxyethyl)amine

1-dodecylbromide
143-15-7

1-dodecylbromide

domiphen brominde
538-71-6

domiphen brominde

n-Dodecylamine
124-22-1

n-Dodecylamine

phenoxyethyl bromide
589-10-6

phenoxyethyl bromide

domiphen brominde
538-71-6

domiphen brominde

Conditions
ConditionsYield
With methyl bromide; formaldehyd; formic acid
N,N-dimethylaminododecane
112-18-5

N,N-dimethylaminododecane

phenoxyethyl bromide
589-10-6

phenoxyethyl bromide

domiphen brominde
538-71-6

domiphen brominde

Conditions
ConditionsYield
With ethyl acetate
With acetone
With water
domiphen brominde
538-71-6

domiphen brominde

3,6-dichloro-2-methoxybenzoate sodium salt
1918-00-9

3,6-dichloro-2-methoxybenzoate sodium salt

dodecyldimethylphenoxyethylammonium 3,6-dichloro-2-methoxybenzoate

dodecyldimethylphenoxyethylammonium 3,6-dichloro-2-methoxybenzoate

Conditions
ConditionsYield
In water99.5%
(R)-Mecoprop
16484-77-8

(R)-Mecoprop

domiphen brominde
538-71-6

domiphen brominde

domiphen (+)-(R)-2-(4-chloro-2-methylphenoxy)propionate
1354725-99-7

domiphen (+)-(R)-2-(4-chloro-2-methylphenoxy)propionate

Conditions
ConditionsYield
Stage #1: (R)-Mecoprop With potassium hydroxide In water at 39.84℃;
Stage #2: domiphen brominde In water for 24h;
99%
MCPA
94-74-6

MCPA

domiphen brominde
538-71-6

domiphen brominde

domiphen (4-chloro-2-methylphenoxy)acetate
1082249-07-7

domiphen (4-chloro-2-methylphenoxy)acetate

Conditions
ConditionsYield
With sodium hydroxide In water for 2h;98%
domiphen brominde
538-71-6

domiphen brominde

L-proline
147-85-3

L-proline

C22H40NO(1+)*C5H8NO2(1-)

C22H40NO(1+)*C5H8NO2(1-)

Conditions
ConditionsYield
With potassium hydroxide In water at 59.84℃; for 12h;92%
N-(phosphonemethyl)glycine
1071-83-6

N-(phosphonemethyl)glycine

domiphen brominde
538-71-6

domiphen brominde

bis(N,N-dimethyl-N-dodecyl-N-phenoxyethylammonium) glyphosate

bis(N,N-dimethyl-N-dodecyl-N-phenoxyethylammonium) glyphosate

Conditions
ConditionsYield
Stage #1: domiphen brominde With potassium hydroxide In 1,4-dioxane at 25℃; for 6h;
Stage #2: N-(phosphonemethyl)glycine In 1,4-dioxane at 25℃; for 6h;
92%

538-71-6Relevant articles and documents

Dentifrice containing a poly(hydroxypropyl ether) non-ionic surfactant and a specified cationic polymer

-

, (2008/06/13)

Dentifrice containing, in combination, (A) a poly(hydroxypropyl ether) nonionic surfactant, and (B) a cationic polymer selected from the group consisting of (i) a vinylpyrrolidone/dialkylaminoalkyl or -hydroxyalkyl acrylate or methacrylate, quaternized or nonquaternized and (ii) a cationic polysaccharide. This dentifrice is characterized by good foamability, pleasant taste and it does not attack the buccal mucosae and the gums.

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