5383-82-4

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
N-(4-CARBOXYPHENYL)PHTHALIMIDE is used as a reagent in the synthesis of various organic compounds, playing a crucial role in the development of new pharmaceutical and agrochemical products.
Used in Photochemistry and Photophysics:
N-(4-CARBOXYPHENYL)PHTHALIMIDE has been studied for its potential applications in the field of photochemistry and photophysics, where its properties can be utilized for various scientific and industrial processes.
Used in Fluorescence-based Sensing and Imaging Applications:
Due to its fluorescence properties, N-(4-CARBOXYPHENYL)PHTHALIMIDE is employed in fluorescence-based sensing and imaging applications, contributing to advancements in analytical chemistry and bioimaging techniques.

InChI:InChI=1/C15H9NO4/c17-13-11-3-1-2-4-12(11)14(18)16(13)10-7-5-9(6-8-10)15(19)20/h1-8H,(H,19,20)/p-1

Upstream product

• 85-44-9 phthalic anhydride 
• 150-13-0 4-amino-benzoic acid 
• 3939-41-1 4-(benzylideneimino)benzoic acid 
• 3485-84-5 N-vinylphthalimide 
• 54376-74-8 2-(4-iodophenyl)isoindoline-1,3-dione 
• 19368-10-6 2-[(4-carboxyphenyl)aminocarbonyl]benzoic acid 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 127934-54-7 methyl 4-(1,3-dioxoisoindolin-2-yl)benzoate 
• 619-45-4 4-methoxycarbonyl aniline 
• 524-38-9 N-hydroxyphthalimide 
• 22509-74-6 N-ethoxycarbonylphthalimide 

Downstream Products

• 108896-18-0 4-phthalimido-benzoic acid vinyl ester 
• 112321-84-3 N-[4-(2,4-dimethoxy-benzoyl)-phenyl]-phthalimide 
• 5383-83-5 4–(1,3-dioxoisoindolin-2-yl)benzoyl chloride 
• 1334395-29-7 triphenylstannyl 4-(1,3-dioxoisoindolin-2-yl) benzoate 

Relevant academic research and scientific papers

Synthesis of phthalimides, isoindolin-1-ones and isoindolines bearing aminobenzoic acids as a new fluorescent compounds

Both experimental and theoretical methods were used in order to study the fluorescent properties of nine new compounds based on phthalimides, isoindolin-1-ones and isoindolines bearing aminobenzoic acids (2-aminobenzoic acid, 3-aminobenzoic acid and 4-aminobenzoic acid), which were obtained under mild reaction conditions. The photophysical properties of all the compounds were studied by electronic absorption and fluorescence spectroscopy in methanol solutions. All compounds exhibited fluorescence emission and high quantum yields. Additionally, it was found that the intramolecular charge in these donor-acceptor systems is significantly depending on electron-withdrawing substituents at the carboxylic acid position.

A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies

Quinoline-isoniazid-phthalimide triads have been synthesised to assess their antiplasmodial efficacy and cytotoxicity against chloroquine-resistant W2 strain of P. falciparum and Vero cells, respectively. Most of the synthesized compounds displayed IC50 in lower nM range and appeared to be approximately five to twelve fold more active than chloroquine. Heme-binding studies were also carried out to delineate the mode of action. The promising compounds with IC50s in range of 11–30 nM and selectivity index >2800, may act as promising template for the design of new antiplasmodials.

Synthesis and anti-inflammatory intestinal activity of new glucocorticoid derivatives

Glucocorticoids (GCs) are used worldwide in the treatment of chronic inflammatory diseases. This study describes the synthesis of new glucocorticoid derivatives and evaluates anti-inflammatory activity in rat models with ulcerative colitis (UC). Six compounds (5a–f) were synthetized using the molecular hybridization strategy with yields of 40–80%. The compounds 5e and 5f showed a total regression of ulceration in 83.3% and 75% of treated animals, respectively. Moreover, 5e improved several clinical signs, such as weight gain and survival rates. The compounds 5a and 5c showed total regression of ulceration in 33.3% of the rats. This is higher than prednisolone. Glucocorticoid derivatives showed potential anti-inflammatory intestinal activity with regression of ulceration in colitis.

Design and synthesis of 4-Aminoquinoline-isoindoline-dione-isoniazid triads as potential anti-mycobacterials

A series of 4-aminoquinoline-isoindoline-dione-isoniazid triads were synthesized and assessed for their anti-mycobacterial activities and cytotoxicity. Most of the synthesized compounds exhibited promising activities against the mc26230 strain of M. tuberculosis with MIC in the range of 5.1–11.9 μM and were non-cytotoxic against Vero cells. The conjugates lacking either isoniazid or quinoline core in their structural framework failed to inhibit the growth of M. tuberculosis; thus, further strengthening the proposed design of triads in the present study.

Amide compounds for regulating WNT signal channel and application of compounds

The invention belongs to the technical field of medicine, and particularly relates to amide compounds for regulating a WNT signal channel and an application of the compounds. The compounds have a structure represented by a general formula I shown in the description.

Synthesis of novel isoindolone-based medium-sized macromolecules and triazole containing heterocyclic compounds

A series of novel isoindolone-based macromolecules of medium-sized heterocyclic rings, such as 7,8-dihydro-6H-benzo[4,5][1,6,3]dioxazonino[2,3-a]isoindol-14(9aH)-one derivatives (5a-l), were synthesized and its frame work incorporating with a triazole moiety on phenol, ie, 2-(4-((1-(2-methoxyphenyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)isoindoline-1,3-dione (9a-f) and also a triazole moiety on carboxylic acid, ie, (1-(2-methoxyphenyl)-1H-1,2,3-triazol-4-yl)methyl 4-(1,3-dioxoisoindolin-2-yl)benzoate derivatives (13a-e) with various substitutions on aryl ring system have synthesized. All the synthesized compounds were characterized and confirmed with IR, 1H NMR, 13C NMR, and ESI mass spectral analysis.

Synthesis, molecular docking, cytotoxicity and antioxidant activity evaluation of isoindoline-1,3-dione derivatives

A variety of amines have been employed to functionalize isobenzofuran-1,3-dione to obtain isoindoline-1,3-dione derivatives in the base free conditions. All the synthesized compounds are screened for their bioactivity through molecular docking, cytotoxicity (against HeLa) and antioxidant activity. ABTS and DPPH are employed to assess the antioxidant activity. Among the synthesized isoindoline-1,3-dione derivatives (3a-k), compound 3e has showed the best antioxidant activity and also exhibited better binding energy when docked with caspase-3 protein. Cytotoxicity of the synthesized compounds was studied against cervical cancer cell line (HeLa) and compound 3e has displayed better activity than other isoindoline derivatives.

A phthalimidation protocol that follows protein defined parameters

This work outlines the first phthalimidation protocol suitable for protein labeling and performed in aqueous media at room temperature and neutral pH with no catalyst or co-reagent required. The methodology is suitable for a range of amines and its efficiency was determined with chemoselective and site-selective protein labeling. This journal is

Thermoplastic polymer composition

The invention provides a compound conforming to the structure of Formula (C) The invention also provides a thermoplastic polymer composition comprising a polyolefin polymer and a compound conforming to the structure of Formula (C) as a nucleating agent.

Bifunctional copper(II) chelators from the coupling of the encapsulating ligand 1-methyl-8-amino-3,13,16-trithia-6,10,19-triazabicyclo[6.6.6]icosane (AMN3S3sar) with carboxylic acids; Applications of the coupling agent DMT-MM

Reaction of 1-methyl-8-amino-3,13,16-trithia-6,10,19-triazabicyclo[6.6.6]icosane (AMN3S3sar) with the amide coupling agent 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM) and 4-nitrobenzoic acid, the protected amine 4-(1,3-dioxoisoindolin-2-yl)benzoic acid and the tricarboxylic acid, benzene-1,3,5-tricarboxylic acid (trimesic acid) resulted in the three new ligands N3S3amideSarArNO2, N3S3amideSarAr, and (AMN3S3sar)3TMA. Two of the respective copper(II) complexes have been isolated and characterized.