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Upstream product

• 34713-70-7 2-Phenylpropanal 
• 78-94-4 methyl vinyl ketone 
• 109141-70-0 1-(1-methoxyprop-1-en-2-yl)benzene 
• 98-86-2 acetophenone 
• 28937-18-0 4-methyl-4-phenyl-cyclohex-2,5-dien-1-one 
• 17429-36-6 4-methyl-4-phenylcyclohex-2-enone 
• 18932-33-7 4-methyl-4-phenylcyclohexan-1-one 
• 119750-80-0 4-((R)-2-[1,3]Dioxolan-2-yl-2-phenyl-propyl)-3,5-dimethyl-isoxazole 

Relevant academic research and scientific papers

Nickel-Catalyzed Desymmetric Hydrogenation of Cyclohexadienones: An Efficient Approach to All-Carbon Quaternary Stereocenters

Nickel-catalyzed desymmetric hydrogenation has been achieved. With the Ni(OTf)2/(S,S)-Ph-BPE system, a series of ?,?-disubstituted cyclohexadienones were transformed to the corresponding cyclohexenones with a chiral all-carbon quaternary center at the γposition in high yields (92-98%) and excellent enantioselectivities (92%-99% ee). This catalytic system can also tolerate the desymmetric reaction of spirocarbocyclic cyclohexadienones to produce the corresponding cyclohexenones bearing a chiral spiro quaternary carbon with high yields (94%-98%) and ee values (96%-99% ee). Furthermore, this methodology provides an efficient and concise synthetic route to the intermediate of natural products cannabispirenones A and B.

Asymmetric Synthesis of Remote Quaternary Centers by Copper-Catalyzed Desymmetrization: An Enantioselective Total Synthesis of (+)-Mesembrine

Catalytic asymmetric syntheses of remote quaternary stereocenters have been developed by copper-catalyzed 1,4-hydrosilylation of ?,?-disubstituted cyclohexadienones. A variety of cyclohexenones have been synthesized in good yield and excellent enantioselectivity. Versatile 2-silyloxy diene intermediates bearing ?,?-disubstituted all carbon stereogenic centers can be isolated from the mild reaction conditions. The utility of this strategy is exemplified in a catalytic asymmetric total synthesis of (+)-mesembrine.

Catalytic Desymmetrizing Dehydrogenation of 4-Substituted Cyclohexanones through Enamine Oxidation

A desymmetrizing dehydrogenation process catalyzed by a chiral primary amine is described herein. The reaction proceeds through the oxidation of a ketone enamine by IBX and enables the highly enantioselective desymmetrization of 4-substituted cyclohexanones with the generation of chiral 4-substituted cyclohexenones containing a remote γ-stereocenter.

Asymmetric Induction at Remote Quaternary Centers of Cyclohexadienones by Rhodium-Catalyzed Conjugate Hydrosilylation

The enantioselective desymmetrizing conjugate hydrosilylation of prochiral differently γ,γ-disubstituted cyclohexadienone derivatives 2 to furnish the corresponding cyclohexenones 4 with a remote chiral all-carbon quaternary center at the γ position is de

A new powerful strategy for the organocatalytic asymmetric construction of a quaternary carbon stereogenic center

(Figure Presented) A new method for chiral diamine-catalyzed Robinson-type annulation was developed to construct cyclohexenone derivatives bearing a quaternary carbon stereogenic center at the 4-position in high enantiomeric excess. This method was successfully applied to the short synthesis of (+)-sporochnol A.

Construction of a Chiral Quaternary Carbon Center by Enantioselective Deprotonation: Application to the Formal Synthesis of (+)-α-Cuparenone

Construction of a chiral quaternary carbon center was achieved by employing an enantioselective deprotonation with chiral bases and this strategy was applied to the formal synthesis of (+)-α-cuparenone.

An Asymmetric Isoxazole Annulation

An asymmetric isoxazole annulation proceeds from the (S)-O-methoxyphenylalaninol imine of (RS)-2-phenylpropionaldehyde (3).Deprotonation, quenching with 4-chloromethyl-3,5-dimethylisoxazole, and hydrolysis produced isoxazolylaldehyde (5), whose structure