17429-36-6

Basic information

• Product Name: 6-Phenyl-6-methyl-1-cyclohexene-3-one
• Synonyms: 4-Methyl-4-phenyl-2-cyclohexen-1-one;4-Phenyl-4-methyl-2-cyclohexene-1-one;6-Phenyl-6-methyl-1-cyclohexene-3-one;4-Methyl-4-phenylcyclohex-2-enone;1-Methyl-2,3-dihydro-[1,1'-biphenyl]-4(1H)-one
• CAS NO: 17429-36-6
• Molecular Formula: C₁₃H₁₄O
• Molecular Weight: 186.25
• Mol File: 17429-36-6.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-Phenyl-6-methyl-1-cyclohexene-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Phenyl-6-methyl-1-cyclohexene-3-one(17429-36-6)
• EPA Substance Registry System: 6-Phenyl-6-methyl-1-cyclohexene-3-one(17429-36-6)

Safety Data

• Hazardous Substances Data: 17429-36-6(Hazardous Substances Data)

Usage

General Description

6-Phenyl-6-methyl-1-cyclohexene-3-one is a chemical compound in the category of cyclohexenones. Cyclohexenones are generally used in organic synthesis and pharmaceutical industries due to their reactivity and versatility. Specifically, they are often utilized as intermediates in the synthesis of various complex molecules. 6-Phenyl-6-methyl-1-cyclohexene-3-one, with a phenyl group and a methyl group attached to the six-membered cyclohexene ring, can be expected to exhibit unique reactivity patterns. Detailed information about this specific compound, including its physical properties, synthesis, and applications, appears to be limited in existing literature and databases, indicating that it may not be widely studied or utilized in current chemical and pharmaceutical practices.

Upstream product

• 34713-70-7 2-Phenylpropanal 
• 78-94-4 methyl vinyl ketone 
• 71385-28-9 2-methyl-2-phenyl-1,5-hexanedione 
• 96455-77-5 (+/-)-1,3-dimethyl-3-phenylcyclopentene 
• 104-93-8 p-methylanizole 
• 71-43-2 benzene 
• 106-44-5 p-cresol 
• 70150-56-0 (+/-)-4-hydroxy-4-methyl-2-cyclohexen-1-one 
• 504-02-9 1,3-cylohexanedione 
• 62952-33-4 3-ethoxy-6-methylcyclohex-2-en-1-one 
• 5323-87-5 3-Ethoxycyclohex-2-en-1-one 
• 98-86-2 acetophenone 
• 109141-70-0 1-(1-methoxyprop-1-en-2-yl)benzene 
• 108-86-1 bromobenzene 

Downstream Products

• 24432-28-8 (R)-1-methyl-2,3-dihydro-[1,1'-biphenyl]-4(1H)-one 
• 53834-74-5 (S)-1-methyl-2,3-dihydro[1,1'-biphenyl]-4(1H)-one 
• 1643566-01-1 diethyl 2-((1R,2R)-1-methyl-4-oxo-1,2,3,4-tetrahydro-[1,1'-biphenyl]-2-yl)malonate 
• 1643566-12-4 tetraethyl 2,2′-(2-methyl-5-oxo-2-phenylcyclohexane-1,3-diyl)dimalonate 

Relevant articles and documents

Rhodium-Catalyzed Desymmetric Arylation of γ,γ-Disubsituted Cyclohexadienones: Asymmetric Synthesis of Chiral All-Carbon Quaternary Centers

The desymmetric arylation of prochiral cyclohexadienones with ArZnCl in the presence of an (R)-segphos-rhodium catalyst gave high yields of the corresponding cyclohexenones, which contain a chiral arylated carbon center at the β-position and a chiral all-carbon quaternary center at the γ-position, with high diastereo- and enantioselectivities. This catalytic system was also applied to the arylation of spirocarbocyclic cyclohexadienones and afforded the corresponding cyclohexenones bearing a chiral spiro quaternary carbon with high dr and ee.

Strong and Confined Acids Control Five Stereogenic Centers in Catalytic Asymmetric Diels–Alder Reactions of Cyclohexadienones with Cyclopentadiene

We describe a highly enantioselective Diels–Alder reaction of cross-conjugated cyclohexadienones with cyclopentadiene, in which five stereocenters are effectively controlled by a strongly acidic and confined imidodiphosphorimidate catalyst. Our approach provides tricyclic products in excellent stereoselectivity. We also report methods to convert the obtained products into useful intermediates and a computational study that aids in gaining deeper insight into the reaction mechanism and origin of stereoselectivity.

Asymmetric Synthesis of Remote Quaternary Centers by Copper-Catalyzed Desymmetrization: An Enantioselective Total Synthesis of (+)-Mesembrine

Catalytic asymmetric syntheses of remote quaternary stereocenters have been developed by copper-catalyzed 1,4-hydrosilylation of ?,?-disubstituted cyclohexadienones. A variety of cyclohexenones have been synthesized in good yield and excellent enantioselectivity. Versatile 2-silyloxy diene intermediates bearing ?,?-disubstituted all carbon stereogenic centers can be isolated from the mild reaction conditions. The utility of this strategy is exemplified in a catalytic asymmetric total synthesis of (+)-mesembrine.