53878-93-6

Basic information

• Product Name: (2-azido-5-chlorophenyl)(phenyl)methanone
• Synonyms: (2-azido-5-chlorophenyl)(phenyl)methanone
• CAS NO: 53878-93-6
• Molecular Weight: 257.679
• Mol File: 53878-93-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (2-azido-5-chlorophenyl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2-azido-5-chlorophenyl)(phenyl)methanone(53878-93-6)
• EPA Substance Registry System: (2-azido-5-chlorophenyl)(phenyl)methanone(53878-93-6)

Safety Data

• Hazardous Substances Data: 53878-93-6(Hazardous Substances Data)

Upstream product

• 719-59-5 5-chloro-2-aminobenzophenone 
• 7440-44-0 pyrographite 

Downstream Products

• 1384487-72-2 C₂₃H₁₆ClN₅O 
• 1334951-15-3 5-chloro-3-phenyl-2-p-tolyl-2H-indazole 
• 1334951-14-2 2-(4-bromophenyl)-5-chloro-3-phenyl-2H-indazole 
• 1334951-13-1 5-chloro-2-(4-methoxyphenyl)-3-phenyl-2H-indazole 
• 31576-84-8 4-(6-chloro-3,4-diphenyl-2-quinolyl)morpholine 
• 130137-31-4 7-Chloro-5-phenyl-[1,2,3]triazolo[1,5-a]quinoline-3,4-dicarboxylic acid diethyl ester 
• 719-64-2 5-chloro-3-phenylanthranil 

Relevant articles and documents

Compound and application of compound to treating colon cancer

The invention discloses a compound and application of the compound to treating the colon cancer. The structural formula of the compound is shown in the formula I, wherein R1, R2, R3 and R4 in the formula I are respectively independently chosen from alkyl groups and alkoxy groups, the number of hydrogen atoms, halogen, nitro and carbon atoms in the alkyl group is 1-6, the number of carbon atoms in the alkoxy group is 1-6, R5 is chosen from nitro and -NR6R7, wherein R6 and R7 are respectively independently the hydrogen atom or CH2Ar, the Ar represents a phenyl group or an aryl group, the para-position of the aryl group is substituted by R8, the aryl group is a phenyl group, the R8 is an alkoxy group or the following shown groups, and the number of halogen, hydroxyl and carbon atoms in the R8 is 1-6. The compound also has an obvious effect on inhibiting a tumor sphere from a cancer patient with the colon cancer. In addition, the compound also has an obvious effect on inhibiting the migration and the moving ability of a colon cancer cell line. A novel medicine for treating the colon cancer is expected to be developed on the basis of the compound.

One-pot, two-step cascade synthesis of quinazolinotriazolobenzodiazepines

An operationally simple, one-pot, two-step cascade method has been developed to afford quinazolino[1,2,3]triazolo[1,4]benzodiazepines. This unique, atom-economical transformation engages five reactive centers (amide, aniline, carbonyl, azide, and alkyne) and employs environmentally benign iodine as a catalyst. The method proceeds via sequential quinazolinone-forming condensation and intramolecular azide-alkyne 1,3-dipolar cycloaddition reactions. Substrate scope, multicomponent examples, and mechanistic insights are discussed.

Intramolecular Fe(II)-Catalyzed N-O or N-N bond formation from aryl azides

(Figure presented) Iron(II) bromide catalyzes the transformation of aryl and vinyl azides with ketone or methyl oxime substituents into 2,1-benzisoxazoles, indazoles, or pyrazoles through the formation of an N-O or N-N bond. This transformation tolerates a variety of different functional groups to facilitate access to a range of benzisoxazoles or indazoles. The unreactivity of the Z-methyloxime indicates that N-heterocycle formation occurs through a nucleophilic attack of the ketone or oxime onto an activated planar iron azide complex.