53932-60-8

Basic information

• Product Name: 5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pent-2-enoic acid
• CAS NO: 53932-60-8
• Molecular Formula: C₁₃H₁₁NO₄
• Molecular Weight: 245.2307
• Mol File: 53932-60-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 470.9°C at 760 mmHg
• Flash Point: 238.6°C
• Density: 1.378g/cm³
• Vapor Pressure: 1.14E-09mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: 5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pent-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pent-2-enoic acid(53932-60-8)
• EPA Substance Registry System: 5-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)pent-2-enoic acid(53932-60-8)

Safety Data

• Hazardous Substances Data: 53932-60-8(Hazardous Substances Data)

Upstream product

• 17137-11-0 3-phthalimidopropionyl chloride 
• 2436-29-5 3-(N-phthaloyl)propionaldehyde 
• 883-44-3 N-(3-hydroxypropyl)phthalimide 
• 600155-23-5 (E)-5-(N-phthalimido)-pent-2-enoic acid tert-butyl ester 
• 136918-14-4 phthalimide 
• 107-02-8 acrolein 

Downstream Products

• 600155-24-6 (4S,2E)-3-[5-(N-phthalimido)-1-oxo-2-pentenyl]-4-phenyl-2-oxazolidinone 

Relevant articles and documents

Stereoselective synthesis of novel dipeptide β-turn mimetics targeting melanocortin peptide receptors

(Matrix presented) The novel dipeptide β-turn mimetic, 4,8-disubstituted azabicyclo[4.3.0]nonane amino acid ester (15), has been synthesized to serve as a peptide mimetic of the dipeptide Phe-Arg, which contains two important pharmacophore elements in melanotropin peptides. Introduction of side-chain functionality at C-8 was achieved by using β-functionalized pyroglutamate (8) as a synthetic precursor. The side chain at C-4 was introduced by bromination of dehydroamino acid intermediate (10) followed by Suzuki cross-coupling.