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54001-07-9

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54001-07-9 Usage

General Description

1-[2-(4-CHLOROPHENYL)-4-METHYL-1,3-THIAZOL-5-YL]-1-ETHANONE, also known as Cimetidine, is a chemical compound that belongs to the family of thiazole derivatives. It is commonly used as a histamine H2 receptor antagonist, which means it blocks the action of histamine on the stomach, reducing the production of stomach acid. This makes it effective in treating conditions such as gastric and duodenal ulcers, gastroesophageal reflux disease, and Zollinger-Ellison syndrome. Cimetidine works by inhibiting the secretion of gastric acid and pepsin, and it has also been found to have antiandrogenic effects, making it useful in the treatment of certain hormone-related conditions such as hirsutism and acne. Despite its therapeutic uses, Cimetidine should be used with caution due to potential drug interactions and side effects.

Check Digit Verification of cas no

The CAS Registry Mumber 54001-07-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,0,0 and 1 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 54001-07:
(7*5)+(6*4)+(5*0)+(4*0)+(3*1)+(2*0)+(1*7)=69
69 % 10 = 9
So 54001-07-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H10ClNOS/c1-7-11(8(2)15)16-12(14-7)9-3-5-10(13)6-4-9/h3-6H,1-2H3

54001-07-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-[2-(4-Chlorophenyl)-4-methyl-1,3-thiazol-5-yl]-1-ethanone

1.2 Other means of identification

Product number -
Other names 1-[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-yl]ethanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:54001-07-9 SDS

54001-07-9Relevant articles and documents

Phenylthiazoles with nitrogenous side chain: An approach to overcome molecular obesity

Elsebaei, Mohamed M.,Abutaleb, Nader S.,Mahgoub, Abdulrahman A.,Li, Daoyi,Hagras, Mohamed,Mohammad, Haroon,Seleem, Mohamed N.,Mayhoub, Abdelrahman S.

, (2019)

A novel series of phenylthiazoles bearing cyclic amines at the phenyl-4 position was prepared with the objective of decreasing lipophilicity and improving the overall physicochemical properties and pharmacokinetic profile of the compounds. Briefly, the pi

Versatile approaches to a library of building blocks based on 5-acylthiazole skeleton

Kulyk, Olesia G.,Biloborodov, Dmytro A.,Cherevatenko, Maksim A.,Shyriakin, Yevhen Y.,Lyapunov, Alexander Yu.,Mazepa, Alexander V.,Vashchenko, Valerii V.,Orlov, Valeriy D.,Kolosov, Maksim A.

supporting information, p. 3616 - 3628 (2020/09/07)

Thiazole derivatives represent an important class of azole heterocycles with a broad spectrum of biological activity and, therefore, the synthesis of these compounds is of remarkable concern. We present here practical and reliable protocol for synthesis of some 5-acylthiazoles and demonstrate their utility in the preparation of several new series of thiazole-containing building blocks through transformation of 5-acyl function. Specifically, thiazole-based alcohols, oximes, primary, and secondary amines were successively synthesized in good to excellent yields. The chemical structures of obtained compounds were confirmed by 1H and 13C NMR-spectroscopy, elemental analysis, and mass-spectrometry.

Synthesis, Characterization, and Antimicrobial Screening of 4″-methyl-2,2″-diaryl-4,2′:4′,5″-terthiazole Derivatives

Nalawade, Jitendra,Mhaske, Pravin C.,Shinde, Abhijit,Patil, Sachin V.,Choudhari, Prafulla B.,Bobade, Vivek D.

, p. 1366 - 1374 (2018/04/25)

A series of novel 4″-methyl-2,2″-diaryl-4,2′:4′,5″-terthiazole (8a-p) derivatives has been synthesized and screened for antibacterial activity against four pathogenic bacteria, Escherichia coli, Pseudomonas flurescence, Staphylococcus aureus, and Bacillus subtilis. Among them, compounds 8a and 8j exhibited excellent antibacterial activity with minimum inhibitory concentration range of 1.0 to 5.3?μg/mL and compounds 8m and 8p exhibited moderate to good antibacterial activity with minimum inhibitory concentration range of 16.9 to 29.7?μg/mL against all tested strains. All the synthesized compounds were screened for their in vitro antifungal activity against Cocinida candida. Most of the compounds reported moderate antifungal activity. This study provides valuable directions to our ongoing endeavor of rationally designing more potent antimicrobial agent.

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