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540741-84-2

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540741-84-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 540741-84-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,4,0,7,4 and 1 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 540741-84:
(8*5)+(7*4)+(6*0)+(5*7)+(4*4)+(3*1)+(2*8)+(1*4)=142
142 % 10 = 2
So 540741-84-2 is a valid CAS Registry Number.

540741-84-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-hydroxyethyl pyridine-2-carboxylate

1.2 Other means of identification

Product number -
Other names 2-Pyridinecarboxylicacid,2-hydroxyethylester(9CI)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:540741-84-2 SDS

540741-84-2Downstream Products

540741-84-2Relevant articles and documents

Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and in vivo antihyperglycaemic efficacy

Chen, Feng,Chen, Jiabao,Gao, Cheng,Li, Junyan,Liu, Siyan,Qian, Shan,Wang, Zhouyu,Yang, Lingling,Zhang, Yuanyuan

, p. 152 - 164 (2019/11/25)

Overexpression of protein tyrosine phosphatase 1B (PTP1B) induces insulin resistance in various basic and clinical research. In our previous work, a synthetic oleanolic acid (OA) derivative C10a with PTP1B inhibitory activity has been reported. However, C10a has some pharmacological defects and cytotoxicity. Herein, a structure-based drug design approach was used based on the structure of C10a to elaborate the smaller tricyclic core. A series of tricyclic derivatives were synthesised and the compounds 15, 28 and 34 exhibited the most PTP1B enzymatic inhibitory potency. In the insulin-resistant human hepatoma HepG2 cells, compound 25 with the moderate PTP1B inhibition and preferable pharmaceutical properties can significantly increase insulin-stimulated glucose uptake and showed the insulin resistance ameliorating effect. Moreover, 25 showed the improved in vivo antihyperglycaemic potential in the nicotinamide–streptozotocin-induced T2D. Our study demonstrated that these tricyclic derivatives with improved molecular architectures and antihyperglycaemic activity could be developed in the treatment of T2D.

Al2O3/MeSO3H (AMA) as a new reagent with high selective ability for monoesterification of diols

Sharghi, Hashem,Sarvari, Mona Hosseini

, p. 3627 - 3633 (2007/10/03)

A new facile method for monoesterification of diols has been developed. A variety of diols, in particular oligoethylene glycols, were selectively monoesterified in excellent yields by reaction with aromatic and aliphatic acids in the presence of Al2O3/MeSO3H as a new reagent without use of any solvents.

Acyl Transfer Reaction Catalyzed by Cu(2+) Ion Complex of a Lipolhilic Hydroxyimidazole-ligand in AOT Reverse Micelles. Effects of Change of Core Solvent from Water to DMF

Fujita, Tsunehisa,Minami, Hajimu,Ogino, Kenji,Tagaki, Waichiro

, p. 2289 - 2292 (2007/10/02)

The transfer of acyl group of p-nitrophenyl picolinate to alcohol acceptors has been investigated kinetically in AOT reverse micelles using hexane and DMF as the bulk and the core solvents, respectively.The reaction was found to be remarkably catalyzed by a 1:2 complex of Cu(2+) ion and N-dodecyl-2-hydroxymethylimidazole ligand involving the acylated ligand as the intermediate.It was also observed that the reaction in the reverse micelles was much faster than in pure DMF.

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