54120-02-4

Basic information

• Product Name: a-(Aminomethyl)-cyclopropanemethanol HCl
• Synonyms: a-(Aminomethyl)-cyclopropanemethanol HCl;2-Amino-1-cyclopropylethan-1-ol
• CAS NO: 54120-02-4
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101.15
• Mol File: 54120-02-4.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: a-(Aminomethyl)-cyclopropanemethanol HCl(CAS DataBase Reference)
• NIST Chemistry Reference: a-(Aminomethyl)-cyclopropanemethanol HCl(54120-02-4)
• EPA Substance Registry System: a-(Aminomethyl)-cyclopropanemethanol HCl(54120-02-4)

Safety Data

• Hazardous Substances Data: 54120-02-4(Hazardous Substances Data)

Upstream product

• 101947-93-7 2-cyclopropyl-2-((trimethylsilyl)oxy)acetonitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 1489-69-6 Cyclopropanecarboxaldehyde 
• 5648-87-3 2-cyclopropyl-2-hydroxyacetonitrile 
• 54120-03-5 1-(cyclopropyl)-2-nitroethanol 

Downstream Products

• 56105-19-2 2-cyclopropylacetaldehyde 
• 121102-91-8 2-t-butoxycarbonylamino-1-cyclopropylethanol 
• 1063734-79-1 2-cyclopropylmorpholine 
• 1255700-87-8 2-cyclopropyl-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-4-methyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepin-8-amine 

Relevant articles and documents

Chiral-Organotin-Catalyzed Kinetic Resolution of Vicinal Amino Alcohols

A highly efficient kinetic resolution of racemic amino alcohols has been achieved for the first time with a chiral tin catalyst. A chiral organotin compound with 3,4,5-trifluorophenyl groups at the 3,3′-positions of the binaphthyl framework enabled this transformation with excellent yield and high enantioselectivity. The process tolerates aryl- and alkyl-substituted amino alcohols and a variety of other substrates, affording the corresponding products in high enantioselectivity and with s factors up to >500.

A One-Pot Reaction toward the Diastereoselective Synthesis of Substituted Morpholines

The diastereoselective synthesis of various substituted morpholines has been achieved from vinyloxiranes and amino-alcohols under sequential Pd(0)-catalyzed Tsuji-Trost/Fe(III)-catalyzed heterocyclization. Using the same strategy, 2,6-, 2,5-, and 2,3-disubstituted as well as 2,5,6- and 2,3,5-trisubstituted morpholines were obtained in good to excellent yields and diastereoselectivities.

A 4-tert-butoxycarbonyl-2-cyclopropyl morphline preparation method

The invention discloses a 4-tert butoxycarbonyl-2-cyclopropyl morpholine preparation method, cycloprogyl dehyde is used as a starting material for cyaniding, reduction, condensation, cyclization, deoxidization and tert butoxycarbonyl protection to obtain a target product, and the compound is an important pharmaceutical intermediate.