56105-19-2

Basic information

• Product Name: 1H-PYRROLO[2,3-B]PYRIDIN-3-YLACETIC ACID
• Synonyms: 1H-PYRROLO[2,3-B]PYRIDIN-3-YLACETIC ACID;2-(1H-PYRROLO[2,3-B]PYRIDIN-3-YL)ACETIC ACID;Cyclopropaneacetaldehyde;Cyclopropyl-acetaldehyde, 50%w/w in toluene
• CAS NO: 56105-19-2
• Molecular Formula: C₅H₈O
• Molecular Weight: 84.12
• Mol File: 56105-19-2.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 105-106℃
• Flash Point: 7.7±7.8℃
• Appearance: /
• Density: 0.954±0.06 g/cm3 (20 ºC 760 Torr)
• Refractive Index: 1.4382 (589.3 nm 25℃)
• CAS DataBase Reference: 1H-PYRROLO[2,3-B]PYRIDIN-3-YLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-PYRROLO[2,3-B]PYRIDIN-3-YLACETIC ACID(56105-19-2)
• EPA Substance Registry System: 1H-PYRROLO[2,3-B]PYRIDIN-3-YLACETIC ACID(56105-19-2)

Safety Data

• Statements: 22-41
• Safety Statements: 26
• Hazardous Substances Data: 56105-19-2(Hazardous Substances Data)

Usage

General Description

1H-Pyrrolo[2,3-b]pyridin-3-ylacetic acid is a chemical compound with potential pharmaceutical properties. It belongs to the class of pyrrolopyridines and has been studied for its potential as an antineoplastic and anti-inflammatory agent. It is a small molecule that has shown to have inhibitory effects on certain enzymes and pathways related to cancer cell growth and inflammation. Research on this compound has shown promising results in preclinical studies, suggesting its potential as a drug candidate for the treatment of cancer and inflammatory diseases.

Upstream product

• 21908-53-2 mercury(II) oxide 
• 7647-01-0 hydrogenchloride 
• 530133-47-2 methyl 3-cyclopropyl-2,3-epoxypropionate 
• 34108-21-9 methyl cyclopropylacetate 
• 6542-60-5 2-cyclopropylacetonitrile 
• 59226-78-7 1-cyclopropyl-1,1-diethoxyethane 
• 79-37-8 oxalyl dichloride 
• 2566-44-1 1-cyclopropylethanol 
• 53432-87-4 ethyl 2-cyclopropyl acetate 
• 54120-03-5 1-(cyclopropyl)-2-nitroethanol 
• 23936-77-8 formylcyclopropane diethyl acetal 
• 54120-02-4 2-amino-(1RS)-1-cyclopropylethanol 

Downstream Products

• 5239-82-7 cyclopropylacetic acid 
• 1610370-86-9 (4-(cyclopropylmethyl)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-5-yl)methanol 
• 1610370-85-8 benzyl 4-(cyclopropylmethyl)-1-(4-((2'-fluoro-5'-methoxy-3-methylbiphenyl-4-yl)methyl)phenyl)-3-(trifluoromethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate 
• 1610370-38-1 (E)-benzyl 4-cyclopropylbut-2-enoate 
• 1355686-90-6 C₂₆H₂₉N₃O₄S 
• 1393125-37-5 (+/-)-methyl 4-(2-cyclopropyl-1-hydroxyethyl)benzoate 
• 1393126-72-1 (+/-)-methyl 3-(4-(2-cyclopropyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)ethyl)benzamido)propanoate 
• 1393126-71-0 (+/-)-methyl 4-(2-cyclopropyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)ethyl)benzoate 
• 1393123-92-6 (+/-)-3-(4-(2-cyclopropyl-1-(4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)ethyl)benzamido)propanoic acid 
• 475171-50-7 N,N-bis(cyclopropylmethyl)-2-ethyl-7-(2-methoxy-4-methylphenyl)pyrazolo[1,5-a]pyridin-3-amine 

Relevant articles and documents

Chiral geminal disilyl alkane compound, synthesis method and applications thereof

The present invention discloses a chiral geminal disilyl alkane compound, which is represented by a formula V, wherein * represents a chiral carbon atom in the formula V. The invention discloses a synthesis method of the chiral geminal disilyl alkane compound, wherein the synthesis method comprises: carrying out a reaction in the presence of a reducing agent by using alkyne represented by a formula I, dihydrosilane represented by a formula II and trihydrosilane represented by a formula III as raw materials and using Xantphos-CoBr2 and a chiral CoX2-OIP complex as catalysts under an inert gas to prepare the chiral geminal disilyl alkane compound represented by the formula V. According to the present invention, the method has characteristics of mild reaction condition, simple operation, highatomic economy, no requirement of the addition of any other toxic transition metals (such as ruthenium, rhodium, palladium and the like) salts, high yield and high enantioselectivity, and has great practical value in the synthesis of drugs and materials, wherein the yield is generally 50-85%, and the enantioselectivity is generally 93-99%. The formulas I, II, III and V are defined in the specification.

Alkylation Reactions of Azodicarboxylate Esters with 4-Alkyl-1,4-Dihydropyridines under Catalyst-Free Conditions

Introduction of alkyl groups on azodicarboxylate esters is an important method to prepare alkyl amine derivatives. Herein, we report reactions of 4-alkyl-1,4-dihydropyridines as alkylation reagents with di-tert-butyl azodicarboxylate to prepare alkyl amin

HETEROARYL COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC USE

Provided herein are heteroaryl compounds, for example, a compound of Formula I or IA, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, ameliorating, or preventing one or more symptoms of a disorder, disease, or condition mediated by a casein kinase 1 (CK1), an interleukin-1 receptor associated kinase (IRAK1), or a cyclin-dependent kinase 9 (CDK9). Formula: (I),(IA)