5413-58-1

Upstream product

• 71-23-8 propan-1-ol 
• 1074-12-0 phenylglyoxal hydrate 
• 611-71-2 MANDELIC ACID 

Downstream Products

• 124-38-9 carbon dioxide 
• 100-52-7 benzaldehyde 
• 106-94-5 propyl bromide 
• 31197-63-4 propyl 2-oxo-2-phenylacetate 
• 1401015-53-9 2-ethyl-4-phenyl-5-ethoxy-1,3-oxazole 
• 1401015-51-7 2-methyl-4-phenyl-5-n-propyloxy-1,3-oxazole 

Relevant academic research and scientific papers

Zirconocene-catalyzed direct (trans)esterification of acyl acids (esters) and alcohols in a strict 1:1 ratio under solvent-free conditions

A highly efficient way for the direct (trans)esterification of acyl acids (esters) and alcohols in a strict 1:1 ratio using a zirconocene complex (1, 1 mol%), a strong Lewis acid of good water tolerance, as a catalyst under solvent-free conditions has been developed. A wide range of acid and alcohol (esters) substrates undergo (trans)esterification to produce carboxylic ester motifs in moderate to good or excellent yields with good functional tolerance, such as that towards C-Br as well as CC and CC bonds. And complex 1 can be recycled six times without showing a significant decline in catalytic efficiency. It was demonstrated that cyclandelate, which is used to treat high blood pressure as well as heart and blood-vessel diseases, can be directly synthesized on a gram scale with 81% yield (6.70 g) using complex 1.

Efficient acid-catalyzed conversion of phenylglyoxal to mandelates on flame-derived silica/Alumina

Amorphous, nonporous silica/alumina (SA) made by flame-spray pyrolysis (FSP) efficiently catalyzes the direct conversion of phenylglyoxal (PG) to alkyl mandelates. The SAs exhibited a turnover frequency more than an order of magnitude higher than dealuminated zeolite Y, which hitherto has been considered as the most active solid acid for this reaction. The free diffusion of PG to surface acid sites and rapid removal of mandelate products are proposed to be at the origin of the superior performance of SAs. The recyclability of the catalyst was tested in five repetitive runs and showed no significant loss of catalyst performance.

A general and simple synthesis of phenylglyoxylic esters via the oxidation of mandelic esters with ammonium chlorochromate adsorbed on alumina

A general method for preparation of phenylglyoxylic esters by oxidation of mandelic esters with readily available ammonium chlorochromate adsorbed on alumina is described.