936-61-8Relevant articles and documents
STUDIES IN FLUORINATED 1,3-DIKETONES AND RELATED COMPOUNDS PART XV. SYNTHESIS AND SPECTROSCOPIC STUDIES OF SOME NEW FLUORINATED MONOTHIO-1,3-DIKETONES
Joshi, Krishna C.,Pathak, Vijai N.
, p. 409 - 412 (1984)
Six new polyfluorinated monothio-1,3-diketones have been synthesized from the corresponding fluorinated acetophenones and appropriate O-alkyl thioesters in the presence of sodamide.All these monothio-1,3-diketones are characterized by I.R. and 1H N.M.R. s
HETEROAROMATIC DERIVATIVES AND PHARMACEUTICAL APPLICATIONS THEREOF
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Paragraph 00726, (2015/11/10)
Provided herein are novel heteroaromatic derivatives, or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a prodrug, a pharmaceutically acceptable salt or a prodrug thereof, and pharmaceutical compositions containing such compounds. Also provided herein are uses of such compounds or pharmaceutical compositions thereof in the manufacture of a medicament for treating respiratory diseases, especially chronic obstructive pulmonary disease (COPD).
Metal-ion catalysis in alkaline ethanolysis of 2-pyridyl thionobenzoate: Effects of modification of electrophilic center from C=O to C=S
Um, Ik-Hwan,Song, Yoon-Ju,Kim, Min-Young,Lee, Jae-In
, p. 1525 - 1529 (2013/07/28)
Pseudo-first-order rate constants (kobsd) have been measured spectrophotometrically for the nucleophilic substitution reactions of 2-pyridyl thionobenzoate (5b) with alkali-metal ethoxides (EtOM, M+ = Li +, Na+, K+, and 18-crown-6-ether complexed K+) in anhydrous ethanol at 25.0 ± 0.1 oC. The plots of kobsd vs. [EtOM]o curve upward regardless of the nature of the M+ ions, while those of kobsd/[EtO -]eq vs. [EtO-]eq are linear with a positive intercept. Dissection of kobsd into kEtO- and kEtOM (i.e., the second-order rate constants for the reactions with the dissociated EtO- and ion-paired EtOM, respectively) has revealed that the ion-paired EtOM is more reactive than the dissociated EtO-, and M+ ions catalyze the reactions in the order K+ Na + Li+ 18C6-complexed K+. The plot of log k EtOM vs. 1/rStokes results in an excellent linear correlation, indicating that the reactions are catalyzed by the solvated M + ions but not by the bare M+ ions. The reactions of 5b with EtOM have been concluded to proceed through a six-membered cyclic TS, in which the solvated M+ ions increase the electrophilicity of the reaction center and the nucleofugality of the leaving group.
