54223-75-5

Upstream product

• 320-72-9 3,5-dichlorosalicylic acid 
• 75-36-5 acetyl chloride 
• 321-14-2 5-chloro-2-hydroxybenzoic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 54223-59-5 4-(2-acetoxy-3,5-dichloro-benzoyl)-morpholine 
• 54223-65-3 10-(2-acetoxy-3,5-dichloro-benzoyl)-10H-phenothiazine 
• 92399-73-0 ethyl N-(2-acetoxy-3,5-dichlorobenzoyl)-N-cyclopentylglycinate 
• 320-72-9 3,5-dichlorosalicylic acid 
• 64-19-7 acetic acid 
• 54223-77-7 2-acetoxy-3,5-dichlorobenzoic acid chloride 
• 1402043-45-1 C₁₂H₇Cl₂N₃O₅S 
• 92399-74-1 N-(3,5-dichloro-2-hydroxybenzoyl)-N-cyclopentylglycine 
• 90791-63-2 1,2-bis(3,5-dichloro-2-hydroxybenzamido)-4,5-dichlorobenzene 

Relevant academic research and scientific papers

SYNTHETIC MYCOTOXIN ADSORBENTS AND METHODS OF MAKING AND UTILIZING THE SAME

The present invention relates generally to molecularly imprinted polymers (MIPs). In particular, the present invention relates to reusable, ecologically friendly MIPs that can be produced in relatively large quantities, methods of producing the same, and

Development of 5-nitrothiazole derivatives: Identification of leads against both replicative and latent Mycobacterium tuberculosis

Twenty eight 5-nitrothiazole derivatives were synthesized and evaluated for in vitro activities against Mycobacterium tuberculosis (MTB), cytotoxicity against HEK 293T. Among the compounds, 5-nitro-N-(5-nitrothiazol-2-yl)furan-2- carboxamide (20) was found to be the most active compound in vitro with MICs of 5.48 μM against log-phase culture of MTB and also non-toxic up to 100 μM.

CHROMENE DERIVATIVES AND USE THEREOF AS HIF HYDROXYLASE ACTIVITY INHIBITORS

The present invention relates to novel compounds of formula (I), methods, and compositions capable of decreasing HIF hydroxylase activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).

Angiotensin converting enzyme inhibitors. (Mercaptoaroyl)amino acids

A series of (mercaptoaroyl)amino acids and related compounds was synthesized and tested for ability to inhibit angiotensin converting enzyme (ACE). The most active compound was N-(3-chloro-2-mercaptobenzoyl)-N-cyclo-pentylglycine, having an in vitro I50 = 0.28 μM. Substitution of the aromatic 3-position by small polar groups enhanced ACE inhibitory activity, whereas bulky groups diminished it. Alteration of the β relationship between the mercaptan and amide carbonyl or masking of the thiol by acylation reduced activity. Replacement of the thiol by nitro, hydroxy, or carboxy gave compounds lacking ACE inhibitory activity.

Synthesis and Evaluation of Diaryl Oxalate Esters for Low-Intensity Chemiluminescent Illumination

Various diaryl oxalate esters have been prepared from oxalyl chloride and substituted salicylates.A number of intermediates and byproducts were obtained from chlorinations of salicylic acid and their mechanistic significance has been discussed.The chemiluminescent emission from the oxalates in the presence of hydrogen peroxide has been examined in the search for low-intensity illumination of at least 10 h duration.Bis(2-alkoxycarbonyl-4,6-dinitrophenyl) oxalates were too unstable while the chemiluminescence of the bis(6-alkoxycarbonyl-2,4,5-trichlorophenyl) oxalates c ould not be adjusted suitably.Some bis(6-alkoxycarbonyl-2,4-dichlorophenyl) oxalates were prepared and, by treatment with various combinations of potassium salicylate and oxalic acid, satisfactory low-intensity light emission could be achieved.