54276-53-8

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 63877-23-6 (trimethylsilyl)acetyl chloride 
• 108-98-5 thiophenol 
• 75-77-4 chloro-trimethyl-silane 
• 151-50-8 potassium cyanide 
• 75-36-5 acetyl chloride 

Downstream Products

• 344561-62-2 trans-1-Cyano-2-phenyl-1-((trimethylsilyl)oxy)cyclopropane 
• 96-04-8 2,3-heptanedione 
• 61529-89-3 3-(2,3,5,6-Tetramethyl-phenyl)-5-trimethylsilanyloxy-4,5-dihydro-isoxazole-5-carbonitrile 
• 431-03-8 dimethylglyoxal 
• 75-77-4 chloro-trimethyl-silane 
• 2857-97-8 trimethylsilyl bromide 
• 70688-35-6 3-bromo-2-ketopropanonitrile 
• 3061-65-2 2-acetoxyacrylonitrile 
• 768-32-1 trimethylphenylsilane 
• 87656-28-8 1-Cyano-2,2-diphenyl-1-((trimethylsilyl)oxy)cyclopropane 

Relevant academic research and scientific papers

A novel heterogeneous synthesis of acyl cyanides catalyzed by PEG400 and zinc iodide

Aroyl cyanides were readily synthesized in moderate yields by the cyanation of aroyl chlorides with dry powdered potassium cyanide under the catalysis of PEG400 and zinc iodide in dichloromethane at room temperature. A preliminary study on the one-pot preparation of acetyl cyanide was also reported.

Thermolysis of acylazo O-trimethylsilyl cyanohydrins: Azoalkanes yielding captodatively substituted radicals

A new synthetic method has been developed for preparing azoalkanes bearing geminal α-cyano and α-trimethylsiloxy groups. While the symmetrical compound 5 decomposes near room temperature to afford, almost entirely, the C-C dimers, the unsymmetrical azoalkane 3 requires heating to 75 °C. The thermolysis activation parameters of 3 and 5 can be rationalized on steric grounds without invoking captodative radical stabilization. A 13C NMR product study of photolyzed 3 in the presence of TEMPO at 21 °C shows that the fate of caged [tert-butyl, 1-trimethylsiloxy-1-cyanoethyl (14)] radical pairs is disproportionation, 17%, cage recombination, 20%, and cage escape, 63%.