543-28-2

Basic information

• Product Name: isobutyl carbamate
• Synonyms: Isobutyl carbamate; NSC 31187; Carbamic acid, 2-methylpropyl ester; Carbamic acid, isobutyl ester (8CI); 2-methylpropyl carbamate
• CAS NO: 543-28-2
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.1463
• EINECS: 208-841-7
• Mol File: 543-28-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 205.2°C at 760 mmHg
• Flash Point: 91.8°C
• Density: 0.987g/cm³
• Vapor Pressure: 0.253mmHg at 25°C
• Refractive Index: 1.427
• CAS DataBase Reference: isobutyl carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: isobutyl carbamate(543-28-2)
• EPA Substance Registry System: isobutyl carbamate(543-28-2)

Safety Data

• Hazardous Substances Data: 543-28-2(Hazardous Substances Data)

Usage

General Description

Isobutyl carbamate, also known as isobutyl urethane, is a chemical compound that is commonly used as a solvent, plasticizer, and as an additive in food and beverage products. It is a colorless, odorless liquid that is compatible with a wide range of other chemicals, and it is often used to improve the viscosity and adhesion of various products. Isobutyl carbamate is also used in the production of pesticides, pharmaceuticals, and personal care products. It is considered to be relatively low in toxicity, but prolonged exposure to high levels of isobutyl carbamate may cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 78-83-1 2-methyl-propan-1-ol 
• 30833-53-5 phtalic acid mono-iso-butyl ester 
• 57-13-6 urea 
• 51-79-6 urethane 
• 543-27-1 isobutyl chloroformate 
• 506-77-4 cyanogen chloride 
• 80037-75-8 chloro-chloroimino-methanesulfenyl chloride 
• 143-33-9 sodium cyanide 
• 53120-90-4 (ethylthio)(isobutoxy)ketone 
• 7664-41-7 ammonia 
• 5663-07-0 hydroxy sulfonylurea 
• 25646-01-9 -essigsaeure 
• 590-28-3 potassium cyanate 
• 1117-15-3 (2,2,2-Trichloro-acetyl)-carbamic acid isobutyl ester 

Downstream Products

• 6319-56-8 NSC 31069 
• 78-83-1 2-methyl-propan-1-ol 
• 15719-64-9 methylammonium carbonate 
• 115-11-7 isobutene 
• 2291-80-7 iso-butyl N-phenylcarbamate 
• 66498-70-2 C₂₄H₄₂NO₇P 
• 66498-53-1 C₁₆H₂₄BrNO₄ 
• 26654-39-7 4,4-dimethyl-1,3-oxazolidin-2-one 
• 66498-65-5 Isobutyl-N-(p-methoxybenzyloxy)carbamat 

Relevant articles and documents

Indium(III)-Catalyzed Synthesis of Primary Carbamates and N-Substituted Ureas

An indium triflate-catalyzed synthesis of primary carbamates from alcohols and urea as an ecofriendly carbonyl source has been developed. Various linear, branched, and cyclic alcohols were converted into the corresponding carbamates in good to excellent yields. This method also provided access to N-substituted ureas by carbamoylation of amines. All the products were obtained by simple filtration or crystallization, without the need for chromatographic purification. Mechanistic investigations suggest that the carbamoylation reaction proceeds through activation of urea by O-coordination with indium, followed by nucleophilic attack by the alcohol or amine on the carbonyl center of urea. The inexpensive and easily available starting materials and catalyst, the short reaction times, and the ease of product isolation highlight the inherent practicality of the developed method.

Superparamagnetic Fe3O4 Nanoparticles in a Deep Eutectic Solvent: An Efficient and Recyclable Catalytic System for the Synthesis of Primary Carbamates and Monosubstituted Ureas

Superparamagnetic Fe3O4 nanoparticles were used to synthesize various primary carbamates as well as monosubstituted and N,N-disubstituted ureas. This efficient phosgene-free process used urea as an eco-friendly carbonyl source in the presence of a biocompatible deep eutectic solvent (DES) to provide an inexpensive and attractive route that afforded the products in moderate to excellent yields. The employed DES serves both a catalytic role and as the green reaction medium. The magnetic nanocatalyst and DES can been reused several times without a significant loss of activity.

Fe3O4@SiO2/Schiff base/Pd complex as an efficient heterogeneous and recyclable nanocatalyst for chemoselective: N -arylation of O -alkyl primary carbamates

An efficient, heterogeneous and cost effective method has been developed using an Fe3O4@SiO2/Schiff base/Pd complex as a magnetic and easily recyclable nanocatalyst for rapid and effective N-arylation of carbamates in good to excellent yield. The catalyst can be easily recovered and reused over six runs without significant decrease in the activity. Further highlights of this protocol are operational simplicity, versatility and relatively short reaction times.