2291-80-7

Basic information

• Product Name: 2-methylpropyl phenylcarbamate
• Synonyms: carbamic acid, N-phenyl-, 2-methylpropyl ester
• CAS NO: 2291-80-7
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.2423
• Mol File: 2291-80-7.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 216°C at 760 mmHg
• Flash Point: 99.6°C
• Density: 1.08g/cm³
• Vapor Pressure: 0.143mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: 2-methylpropyl phenylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylpropyl phenylcarbamate(2291-80-7)
• EPA Substance Registry System: 2-methylpropyl phenylcarbamate(2291-80-7)

Safety Data

• Hazardous Substances Data: 2291-80-7(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 543-27-1 isobutyl chloroformate 
• 44396-74-9 isobutylzinc iodide 
• 103-71-9 phenyl isocyanate 
• 591-50-4 iodobenzene 
• 543-28-2 isobutylcarbamate 
• 78-83-1 2-methyl-propan-1-ol 
• 124-38-9 carbon dioxide 
• 201230-82-2 carbon monoxide 
• 108-86-1 bromobenzene 
• 590-28-3 potassium cyanate 
• 1919-48-8 2,4,6-triphenoxy-1,3,5-triazine 
• 513-36-0 isobutyryl chloride 
• 78-77-3 Isobutyl bromide 

Downstream Products

• 36622-84-1 N-(methyl-d₃)aniline 
• 78-83-1 2-methyl-propan-1-ol 
• 103-71-9 phenyl isocyanate 

Relevant articles and documents

Nickel-Catalyzed Synthesis of N-(Hetero)aryl Carbamates from Cyanate Salts and Phenols Activated with Cyanuric Chloride

A simple and efficient domino reaction has been designed and employed for the one-pot synthesis of N-(hetero)aryl carbamates through the reaction between alcohols and in-situ produced (hetero)aryl isocyanates in the presence of a nickel catalyst. The phenolic C?O bond was activated via the reaction of phenol with cyanuric chloride (2,4,6-trichloro-1,3,5-triazine (TCT)) as an inexpensive and readily available reagent. This strategy provides practical access to N-(hetero)aryl carbamates in good yields with high functional groups compatibility.

Carbon dioxide utilization in the efficient synthesis of carbamates by deep eutectic solvents (DES) as green and attractive solvent/catalyst systems

A green and eco-friendly solvent/catalyst system based on a deep eutectic solvent (DES) was devised and developed for the simple synthesis of carbamates through three-component coupling of amines, alkyl halides and carbon dioxide (CO2). It was found that choline chloride:zinc(ii) chloride ([ChCl][ZnCl2]2) was very proficient and effective for the activation and utilization of CO2 in carbamate formation reactions from a wide scope of amines. Surprisingly, this strategy provides the desired carbamates under atmospheric CO2 pressure at room temperature. In particular, both aromatic and aliphatic amines were effective and demonstrated excellent yields. Besides, the [ChCl][ZnCl2]2 exhibited very high stability and also could be reused for at least five consecutive cycles without any significant loss of activity. It is worth noting that this is the first solvent/catalyst system which can be recycled successfully from the reaction mixture.

Direct Catalytic Synthesis of N-Arylcarbamates from CO2, Anilines and Alcohols

The direct catalytic synthesis of carbamates from CO2, amines and methanol was achieved by controlling both the reaction equilibrium and the reactivity of the three components. The combination of CeO2 and 2-cyanopyridine was an effective catalyst, providing various carbamates including N-arylcarbamates in high selectivities.