5432-28-0

Basic information

• Product Name: N-nitroso-N-methylcyclohexylamine
• Synonyms: N-nitroso-N-methylcyclohexylamine;METHYLCYCLOHEXYLNITROSAMINE;CYCLOHEXYLAMINE,N-METHYL-N-NITROSO-;N-NITROSOMETHYLCYCLOHEXYLAMINE;N-Methyl-N-nitrosocyclohexylamine
• CAS NO: 5432-28-0
• Molecular Formula: C₇H₁₄N₂O
• Molecular Weight: 142.23
• Mol File: 5432-28-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 259.79°C (rough estimate)
• Flash Point: 109.1°C
• Appearance: /
• Density: 1.0520 (rough estimate)
• Vapor Pressure: 0.0242mmHg at 25°C
• Refractive Index: 1.4880 (estimate)
• PKA: -3.14±0.20(Predicted)
• CAS DataBase Reference: N-nitroso-N-methylcyclohexylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-nitroso-N-methylcyclohexylamine(5432-28-0)
• EPA Substance Registry System: N-nitroso-N-methylcyclohexylamine(5432-28-0)

Safety Data

• Hazardous Substances Data: 5432-28-0(Hazardous Substances Data)

Usage

Safety Profile

Poison by ingestion, intravenous,and intraperitoneal routes. Questionable carcinogen withexperimental tumorigenic data. Mutation data reported.Many N-nitroso compounds are carcinogens. Whenheated to decomposition it emits toxic fumes of NOx. Seealso

InChI:InChI=1/C7H14N2O/c1-9(8-10)7-5-3-2-4-6-7/h7H,2-6H2,1H3

Upstream product

• 60-29-7 diethyl ether 
• 98-94-2 N,N-dimethyl-cyclohexanamine 
• 611-75-6 bromhexine monohydrochloride 
• 100-60-7 N-methylcyclohexylamine 

Downstream Products

• 33668-52-9 1-methyl-1-cyclohexylhydrazine 
• 14300-39-1 N-Cyclohexyl-formamidoxim 
• 97379-92-5 2-Hydroxy-thiobenzoesaeure-(N²-methyl-N²-cyclohexyl-hydrazid) 
• 100-60-7 N-methylcyclohexylamine 
• 55984-45-7 C₂₀H₂₄N₂O₂ 

Relevant articles and documents

Facile N-nitrosation of secondary amines using poly(N,N'-dibromo-Nethylene- benzene-1,3-disulfonamide) and N,N,N′,N′-tetrabromobenzene-1,3- disulfonamide/NaNO2 under mild conditions

In this research project, a combination of poly(N,N′-dibromo-N- ethylene-benzene-1,3-disulfonamide) [PBBS] and/or (N,N,N′,N′- tetrabromobenzene-1,3-disulfonamide) [TBBDA] with sodium nitrite in the presence of wet SiO2 (50% w/w) was used as an efficient nitrosating agent for the conversion of secondary amines to their corresponding nitroso compounds. N-Nitrosation reaction has been performed in dichloromethane at room temperature under mild and heterogeneous conditions. The reaction is operationally simple and corresponding products were achieved in good to excellent yields.

Ph3P/Br2/n-Bu4NNO2 as an efficient system for the preparation of N-nitrosamines and azides

The combination PPh3/Br2/n-Bu4NNO2 was developed as a new reagent system for the efficient preparation of N-nitrosamines and azides from the corresponding amines and hydrazine derivatives, respectively, at 0 °C to room temperature, in excellent yields.

Molybdate sulfuric acid/NaNO2: A novel heterogeneous system for the N-nitrosation of secondary amines under mild conditions

Wet molybdate sulfuric acid (=dioxo[bis(sulfato-κO)]molybdenum; MSA), a new solid acid, can be used in combination with sodium nitrite (NaNO 2) to transform a variety of secondary amines to the corresponding N-nitroso compounds under mild, heterogeneous conditions (Table). The process has several advantages: the reagents are inexpensive and non-hazardous, the reaction is clean, fast, and high-yielding, and MSA can be readily removed by filtration and re-used (after treatment with HCl) without loss of activity. Further, only N-nitrosation was observed, but no C- or O-nitrosation.