54325-28-9Relevant articles and documents
Effect of branching density on avidity of hyperbranched glycomimetics for mannose binding lectin
Lin, Kenneth,Kasko, Andrea M.
, p. 350 - 357 (2013)
Hyperbranched glycopolymers containing mannose units in the branch point were synthesized through the copolymerization of a mannose inimer and mannose acrylate via atom transfer radical polymerization (ATRP). Incorporating a saccharide residue at the branch point results in a closer analogue to natural branched polysaccharides. Gel permeation chromatography characterization of the polymers qualitatively indicates branching in samples from polymerizations utilizing the mannose inimer. Deprotection of the acetate protecting groups from the hyperbranched mannose polymers yields water-soluble polymers that interact with mannose binding lectin (MBL), a key protein of the innate immunity complement system. MBL interaction increases with increasing polymer molecular weight and increasing branching density. Notably, incorporating mannose into the branching repeat unit also increases the interaction of the glycopolymers with MBL compared with glycopolymers with the same branching density but with no mannose at the branch point.
INHIBITORS OF MALARIAL AND PLASMODIUM FALCIPARUM HEXOSE TRANSPORTER AND USES THEREOF
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Paragraph 00504, (2021/08/14)
Provided are molecules capable of binding to binding pockets of Plasmodium falciparum hexose transporter (PfHT) or analogs thereof and complexes comprising the same. Also provided herein are inhibitors of PfHT, pharmaceutical compositions comprising the i
Total synthesis of agalloside, isolated from: Aquilaria agallocha, by the 5-O-glycosylation of flavan
Arai, Midori A.,Yamaguchi, Yumi,Ishibashi, Masami
, p. 5025 - 5032 (2017/07/10)
Agalloside (1) is a neural stem cell differentiation activator isolated from Aquilaria agallocha by our group using Hes1 immobilized beads. We conducted the first total synthesis of agalloside (1) via the 5-O-glycosylation of flavan 25 using glycosyl fluoride 20 in the presence of BF3·Et2O. Subsequent oxidation with DDQ to flavanone 2 and deprotection successively provided agalloside (1). This synthetic strategy holds promise for use in the synthesis of 5-O-glycosylated flavonoids. The synthesized agalloside (1) accelerated neural stem cell differentiation, which is a result comparable to that for the naturally occurring compound 1.
pyrimidine, pyrazole and pyrazolopyrimidine fused carbohybrid heterocycle compound library, and the preparation method thereof
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Paragraph 0107-0108, (2016/10/08)
The present invention relates to a carbohybrid heterocycle compound library having pyrimidine, pyrazole, and pyrazolopyrimidine fused on a carbohybrid-based molecular frame.