5433-86-3

Basic information

• Product Name: N-(4-acetylphenyl)-4-nitrobenzenesulfonamide
• Synonyms: benzenesulfonamide, N-(4-acetylphenyl)-4-nitro-; N-(4-Acetyl-phenyl)-4-nitro-benzenesulfonamide
• CAS NO: 5433-86-3
• Molecular Formula: C₁₄H₁₂N₂O₅S
• Molecular Weight: 320.3205
• Mol File: 5433-86-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 528.3°C at 760 mmHg
• Flash Point: 273.3°C
• Density: 1.443g/cm³
• Vapor Pressure: 3E-11mmHg at 25°C
• Refractive Index: 1.633
• CAS DataBase Reference: N-(4-acetylphenyl)-4-nitrobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-acetylphenyl)-4-nitrobenzenesulfonamide(5433-86-3)
• EPA Substance Registry System: N-(4-acetylphenyl)-4-nitrobenzenesulfonamide(5433-86-3)

Safety Data

• Hazardous Substances Data: 5433-86-3(Hazardous Substances Data)

Upstream product

• 99-92-3 p-aminobenzophenone 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 900537-32-8 N-methyl-N-nosyl-p-aminoacetophenone 
• 951658-86-9 4'-(4-nitrobenzenesulfonamide)-4-hydroxychalcone 
• 951658-92-7 4'-(4-nitrobenzenesulfonamide)-3,4-dihydroxychalcone 
• 1383579-59-6 5-[(4-acetylphenylamino)methyl]-2-(methylthio)furo[2,3-d]pyrimidin-4-amine 
• 1383579-49-4 N-(4-acetylphenyl)-N-({4-amino-2-(methylthio)furo[2,3-d]pyrimidin-5-yl}methyl)-4-nitrobenzenesulfonamide 
• 17687-47-7 mono-N-methylaminoacetophenone 
• 3406-75-5 2-(4-nitrophenylthio)acetic acid 
• 19837-78-6 N-(4-acetylphenyl)-4-aminobenzenesulfonamide 

Relevant articles and documents

QUINOLINE DERIVATIVES AND USES IN MANAGING CANCER

Provided herein are compounds, pharmaceutical compositions including such compounds, and methods of using such compounds to treat diseases or disorders associated with MDM2 activity.

Discovery and structure-activity relationship of novel 4-hydroxy-thiazolidine-2-thione derivatives as tumor cell specific pyruvate kinase M2 activators

Pyruvate kinase M2 isoform (PKM2) is a crucial protein responsible for aerobic glycolysis of cancer cells. Activation of PKM2 may alter aberrant metabolism in cancer cells. In this study, we discovered a 4-hydroxy-thiazolidine-2-thione compound 2 as a novel PKM2 activator from a random screening of an in-house compound library. Then a series of novel 4-hydroxy-thiazolidine-2-thione derivatives were designed and synthesized for screening as potent PKM2 activators. Among these, some compounds showed higher PKM2 activation activity than lead compound 2 and also exhibited significant anti-proliferative activities on human cancer cell lines at nanomolar concentration. The compound 5w was identified as the most potent antitumor agent, which showed excellent anti-proliferative effects with IC50 values from 0.46 μM to 0.81 μM against H1299, HCT116, Hela and PC3 cell lines. 5w also showed less cytotoxicity in non-tumor cell line HELF compared with cancer cells. In addition, Preliminary pharmacological studies revealed that 5w arrests the cell cycle at the G2/M phase in HCT116 cell line. The best PKM2 activation by compound 5t was rationalized through docking studies.

Inhibitory evaluation of sulfonamide chalcones on β-secretase and acylcholinesterase

The action of β-secretase (BACE1) is strongly correlated with the onset of Alzheimer's disease (AD). Aminochalcone derivatives were examined for their ability to inhibit BACE1. Parent aminochalcones showed two digit micromolar IC50s against BACE1. Potency