54378-77-7

Basic information

• Product Name: 3,5-difluorothioanisole
• Synonyms: 3,5-difluorothioanisole;(3,5-difluorophenyl)(methyl)sulfane
• CAS NO: 54378-77-7
• Molecular Formula: C₇H₆F₂S
• Molecular Weight: 160.1843464
• Mol File: 54378-77-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,5-difluorothioanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-difluorothioanisole(54378-77-7)
• EPA Substance Registry System: 3,5-difluorothioanisole(54378-77-7)

Safety Data

• Hazardous Substances Data: 54378-77-7(Hazardous Substances Data)

Upstream product

• 616-38-6 carbonic acid dimethyl ester 
• 210532-25-5 3,5-difluorobenzenesulfonyl chloride 
• 100-68-5 methyl-phenyl-thioether 
• 64248-63-1 3,5-difluorobenzonitrile 
• 1879-16-9 1-methoxy-4-methylsulfanyl-benzene 
• 624-92-0 Dimethyldisulphide 
• 2265-91-0 1,3-difluoro-5-iodobenzene 
• 99389-26-1 3,5-difluorobenzenethiol 
• 74-88-4 methyl iodide 

Downstream Products

• 1620013-29-7 N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(methylsulfinyl)phenyl]-5-fluoropyridine-2-carboxamide 
• 1620013-34-4 N-{4-[(3S,5R)-3-amino-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(methylsulfinyl)phenyl]-5-fluoropyridine-2-carboxamide 
• 1620015-21-5 C₃₁H₃₄F₃N₅O₄S 
• 1620013-31-1 C₃₁H₃₄F₃N₅O₅S 
• 1620013-36-6 C₃₂H₃₆F₃N₅O₅S 
• 1620013-41-3 C₃₁H₃₄F₃N₅O₆S 
• 1355011-26-5 methyl 6-[2,6-difluoro-4-(methylthio)phenyl]-5-fluoropyridine-2-carboxylate 
• 1395280-96-2 6-[2,6-difluoro-4-(methylthio)phenyl]-5-fluoropyridine-2-carboxylic acid 
• 1620013-26-4 4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-3-[({6-[2,6-difluoro-4-(methylthio)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate 
• 1620013-25-3 N-{4-[(3S)-3-aminopiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-[2,6-difluoro-4-(methylthio)phenyl]-5-fluoropyridine-2-carboxamide 
• 1395985-67-7 methyl 6-[2,6-difluoro-4-(methylsulfinyl)phenyl]-5-fluoropyridine-2-carboxylate 
• 1395985-74-6 6-[2,6-difluoro-4-(methylsulfinyl)phenyl]-5-fluoropyridine-2-carboxylic acid 
• 1620013-30-0 4-{(3S)-3-[(tert-butoxycarbonyl)amino]piperidin-1-yl}-3-[({6-[2,6-difluoro-4-(methylsulfinyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate 
• 1620013-35-5 4-{(3S,5R)-3-[(tert-butoxycarbonyl)amino]-5-methylpiperidin-1-yl}-3-[({6-[2,6-difluoro-4-(methylsulfinyl)phenyl]-5-fluoropyridin-2-yl}carbonyl)amino]-6,7-dihydro-5H-cyclopenta[b]pyridin-7-yl acetate 

Relevant articles and documents

Synthesis of Aryl Methyl Sulfides from Arysulfonyl Chlorides with Dimethyl Carbonate as the Solvent and C1 Source

A new procedure for the synthesis of aryl methyl sulfides from dimethyl carbonate (DMC) and arylsulfonyl chlorides has been achieved. In this strategy, DMC plays a dual role as both, C1 building block and green solvent. Arylsulfonyl chlorides served as the sulfur precursors, and a variety of aryl methyl sulfides were obtained in moderate to excellent yields with good functional group tolerance. Additionally, alkylsulfonyl chloride and dibenzyl carbonate are proven to be suitable substrates as well.

A visible-light photocatalytic thiolation of aryl, heteroaryl and vinyl iodides

The general catalytic synthesis of aryl and vinyl thioethers from readily available halides remains a challenge. Herein we report a unified method for the thiolation of aryl and vinyl iodides with dialkyl disulfides using visible light photoredox catalysis. A range of thioether products bearing diverse functional groups can be accessed in high yield and with excellent chemoselectivity. We demonstrate the versatility of this method through the expedient synthesis of a family of thioether-rich natural products. A detailed investigation of the photocatalytic mechanism is presented from both steady-state and time-resolved luminescent quenching as well as transient absorption spectroscopy experiments.