5439-80-5Relevant articles and documents
QUINOLINES DERIVATIVES AS NOVEL ANTICANCER AGENTS
-
Page/Page column 93, (2014/10/03)
The invention provides quinoline derivatives, their manufacture, pharmaceutical compositions containing them, and their use as medicaments. The active compounds of the present invention are useful for the treatment of proliferative neoplastic and nonneoplastic diseases.
Microwave-irradiated synthesis and antimicrobial activity of 2-phenyl-7-substitutedalkyl/arylaminoquinoline-4-carboxylic acid derivatives
Bhatt, Hardik G.,Agrawal, Yadvendra K.
experimental part, p. 392 - 402 (2011/02/25)
This report focuses on the synthesis of 2-phenyl-7-substitutedquinoline-4- carboxylic acid derivatives through both conventional and microwave-irradiated methods. Intermediate 7-chloro-2-phenyl-quinoline-4-carboxylic acid was synthesized by condensation a
Microwave-assisted Doebner synthesis of 2-phenylquinoline-4-carboxylic acids and their antiparasitic activities
Muscia, Gisela C.,Carnevale, Juan P.,Bollini, Mariela,Asis, Silvia E.
, p. 611 - 614 (2008/09/19)
(Chemical Equation Presented) A series of twelve substituted 2-phenylquinoline-4-carboxylic acids analogous to antimalarial and antileishmanial natural products was developed via the Doebner reaction employing microwave irradiation (MW). The products were obtained in moderate yields in 0.5-3 minutes and nine of them were evaluated in vitro against the parasites responsible for malaria, leishmaniasis and trypanosomiasis diseases (WHO, Switzerland). Four compounds exhibited activity against Trypanosoma cruzi and another two resulted active against Plasmodium falciparum and Leishmania infantum, respectively.