5439-80-5

Basic information

• Product Name: 4-QUINOLINECARBOXYLIC ACID,7-CHLORO-2-PHENYL-
• Synonyms: 4-QUINOLINECARBOXYLIC ACID,7-CHLORO-2-PHENYL-
• CAS NO: 5439-80-5
• Molecular Formula: C₁₆H₁₀ClNO₂
• Molecular Weight: 283.71
• Mol File: 5439-80-5.mol

Chemical Properties

• Boiling Point: 484.9°C at 760 mmHg
• Flash Point: 247°C
• Appearance: /
• Density: 1.373g/cm³
• Vapor Pressure: 3.25E-10mmHg at 25°C
• Refractive Index: 1.686
• CAS DataBase Reference: 4-QUINOLINECARBOXYLIC ACID,7-CHLORO-2-PHENYL-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-QUINOLINECARBOXYLIC ACID,7-CHLORO-2-PHENYL-(5439-80-5)
• EPA Substance Registry System: 4-QUINOLINECARBOXYLIC ACID,7-CHLORO-2-PHENYL-(5439-80-5)

Safety Data

• Hazardous Substances Data: 5439-80-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H10ClNO2/c17-11-6-7-12-13(16(19)20)9-14(18-15(12)8-11)10-4-2-1-3-5-10/h1-9H,(H,19,20)

Upstream product

• 108-42-9 3-chloro-aniline 
• 100-52-7 benzaldehyde 
• 7519-65-5 N-(3-chlorobenzylidene)aniline 
• 127-17-3 2-oxo-propionic acid 
• 6341-92-0 6-chloroisatin 
• 98-86-2 acetophenone 

Downstream Products

• 1162663-03-7 7-(carboxymethylamino)-2-phenylquinoline-4-carboxylic acid 
• 1162662-99-8 2-phenyl-7-ureidoquinoline-4-carboxylic acid 
• 1162662-96-5 2-phenyl-7-(phenylamino)quinoline-4-carboxylic acid 
• 1162663-00-4 2-phenyl-7-thioureidoquinoline-4-carboxylic acid 
• 1162662-98-7 2-phenyl-7-(4-sulfamoylphenylamino)quinoline-4-carboxylic acid 
• 1162662-95-4 7-(4-nitrophenylamino)-2-phenylquinoline-4-carboxylic acid 
• 1162663-02-6 7-(4-methoxyphenylamino)-2-phenylquinoline-4-carboxylic acid 
• 1162662-94-3 2-phenyl-7-(p-tolylamino)quinoline-4-carboxylic acid 
• 1162663-04-8 7-(4H-1,2,4-triazol-4-ylamino)-2-phenylquinoline-4-carboxylic acid 
• 1162663-05-9 2-phenyl-7-(pyridin-4-ylamino)quinoline-4-carboxylic acid 
• 1162663-01-5 2-phenyl-7-(thiazol-2-ylamino)quinoline-4-carboxylic acid 

Relevant articles and documents

QUINOLINES DERIVATIVES AS NOVEL ANTICANCER AGENTS

The invention provides quinoline derivatives, their manufacture, pharmaceutical compositions containing them, and their use as medicaments. The active compounds of the present invention are useful for the treatment of proliferative neoplastic and nonneoplastic diseases.

STAT3 INHIBITOR CONTAINING QUINOLINECARBOXAMIDE DERIVATIVE AS ACTIVE INGREDIENT

The present invention provides a STAT3 inhibitor containing as an active ingredient, a quinolinecarboxamide derivative represented by the formula (I) (in the formula, W represents a bond or an alkylene chain; X represents O, S, or NR34; and Rs

Microwave-irradiated synthesis and antimicrobial activity of 2-phenyl-7-substitutedalkyl/arylaminoquinoline-4-carboxylic acid derivatives

This report focuses on the synthesis of 2-phenyl-7-substitutedquinoline-4- carboxylic acid derivatives through both conventional and microwave-irradiated methods. Intermediate 7-chloro-2-phenyl-quinoline-4-carboxylic acid was synthesized by condensation a

One-pot synthesis of quinoline-4-carboxylic acid derivatives in water: Ytterbium perfluorooctanoate catalyzed Doebner reaction

Ytterbium perfluorooctanoate [Yb(PFO)3] has been proved to be an efficient catalyst for Doebner reaction of pyruvic acid, aldehydes and amines under mild conditions in water to afford quinoline-4-caboxylic acid derivatives with three component one-pot method in good yields. The process is operationally simple and environmentally benign and the catalyst has readily been recycled for several times with consistent activity. Furthermore, a plausible mechanism for this transformation is also presented.

Microwave-assisted Doebner synthesis of 2-phenylquinoline-4-carboxylic acids and their antiparasitic activities

(Chemical Equation Presented) A series of twelve substituted 2-phenylquinoline-4-carboxylic acids analogous to antimalarial and antileishmanial natural products was developed via the Doebner reaction employing microwave irradiation (MW). The products were obtained in moderate yields in 0.5-3 minutes and nine of them were evaluated in vitro against the parasites responsible for malaria, leishmaniasis and trypanosomiasis diseases (WHO, Switzerland). Four compounds exhibited activity against Trypanosoma cruzi and another two resulted active against Plasmodium falciparum and Leishmania infantum, respectively.