54430-46-5Relevant articles and documents
Asymmetric synthesis of α-(heteroaryl)alkylamines and α-amino acids via nucleophilic 1,2-addition of lithiated heterocycles to aldehyde SAMP-hydrazones
Enders, Dieter,Del Signore, Giuseppe,Raabe, Gerhard
, p. 492 - 518 (2013/08/23)
The asymmetric synthesis of α-(heteroaryl)alkylamines was accomplished by employing a diastereoselective nucleophilic 1,2-addition of lithiated aromatic heterocycles to aldehyde SAMP-hydrazones, followed by BH 3·THF or SmI2 promoted removal of the chiral auxiliary. The CBz or benzoyl-protected amines were obtained in good yields (40%-78%) and excellent enantiomeric excesses (ee = 88%-99%). The methodology can be applied to the synthesis of highly enantioenriched α-amino acids (ee = 90%-99%). TUeBITAK.
Diastereoselective Addition of Organometallic Reagents to Imines or Hydrazones Containing 1,3-Oxathiane As a Chiral Template
Matsubara, Seijiro,Ukita, Hideo,Kodama, Tomohiro,Utimoto, Kiitiro
, p. 831 - 834 (2007/10/02)
The addition of organometallic reagents to imines or hydrazones containing 1,3-oxathiane as a chiral auxiliary proceeded with high diastereoselectivity and can be used as a key reaction for the preparation of chiral β-amino alcohols.
SUBSTITUTED PROLINE COMPOUNDS, COMPOSITION AND METHOD OF USE
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, (2008/06/13)
Compounds of the formula STR1 are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.