54430-46-5

Basic information

• Product Name: BZ-NLE-OH
• Synonyms: BENZOYL-L-2-AMINOHEXANOIC ACID;BENZOYL-L-NORLEUCINE;BZ-NLE-OH;BZO-ACPO(2)-OH;BZO-AHX(2)-OH;BZO-NLE-OH;(S)-alpha-Butylhippuric acid;N-Benzoyl-L-norleucine
• CAS NO: 54430-46-5
• Molecular Formula: C₁₃H₁₇NO₃
• Molecular Weight: 235.28
• Mol File: 54430-46-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 466.2°C at 760 mmHg
• Flash Point: 235.8°C
• Appearance: /
• Density: 1.134g/cm³
• Vapor Pressure: 1.71E-09mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: BZ-NLE-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BZ-NLE-OH(54430-46-5)
• EPA Substance Registry System: BZ-NLE-OH(54430-46-5)

Safety Data

• Hazardous Substances Data: 54430-46-5(Hazardous Substances Data)

Usage

General Description

BZ-NLE-OH is a synthetic opioid compound that belongs to the benzamide class of opioids. It is derived from the chemical structure of fentanyl and is a potent μ-opioid receptor agonist. BZ-NLE-OH has a high affinity for the opioid receptors in the brain, leading to powerful analgesic and sedative effects. It is also known for its high potency and potential for abuse, making it a controlled substance in many countries. The chemical structure of BZ-NLE-OH gives it a long duration of action, making it attractive for medical use in managing severe pain, but also increasing the risk of overdose and addiction. It is important for healthcare professionals to use caution when prescribing and monitoring the use of this powerful opioid.

InChI:InChI=1/C13H17NO3/c1-2-3-9-11(13(16)17)14-12(15)10-7-5-4-6-8-10/h4-8,11H,2-3,9H2,1H3,(H,14,15)(H,16,17)/t11-/m0/s1

Upstream product

• 1469876-41-2 C₂₂H₃₀N₂O₃ 
• 1469876-47-8 (S)-N-(1-furan-2-yl-pentyl)benzamide 
• 72170-91-3 ((S)-2-Methoxymethyl-pyrrolidin-1-yl)-pent-(Z)-ylidene-amine 
• 327-57-1 L-Norleucine 
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Relevant articles and documents

Asymmetric synthesis of α-(heteroaryl)alkylamines and α-amino acids via nucleophilic 1,2-addition of lithiated heterocycles to aldehyde SAMP-hydrazones

The asymmetric synthesis of α-(heteroaryl)alkylamines was accomplished by employing a diastereoselective nucleophilic 1,2-addition of lithiated aromatic heterocycles to aldehyde SAMP-hydrazones, followed by BH 3·THF or SmI2 promoted removal of the chiral auxiliary. The CBz or benzoyl-protected amines were obtained in good yields (40%-78%) and excellent enantiomeric excesses (ee = 88%-99%). The methodology can be applied to the synthesis of highly enantioenriched α-amino acids (ee = 90%-99%). TUeBITAK.

Diastereoselective Addition of Organometallic Reagents to Imines or Hydrazones Containing 1,3-Oxathiane As a Chiral Template

The addition of organometallic reagents to imines or hydrazones containing 1,3-oxathiane as a chiral auxiliary proceeded with high diastereoselectivity and can be used as a key reaction for the preparation of chiral β-amino alcohols.

SUBSTITUTED PROLINE COMPOUNDS, COMPOSITION AND METHOD OF USE

Compounds of the formula STR1 are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.