54430-46-5

Usage

Uses

Used in Pain Management:
BZ-NLE-OH is used as an analgesic agent for the management of severe pain due to its high potency and long duration of action. Its strong affinity for the μ-opioid receptors in the brain allows it to provide effective pain relief for patients suffering from chronic or acute pain conditions.
Used in Palliative Care:
In palliative care, BZ-NLE-OH is used as a potent analgesic to alleviate the intense pain experienced by patients with advanced illnesses, such as cancer. Its long-lasting effects can help improve the quality of life for these patients by providing sustained pain relief.
Used in Anesthesia:
BZ-NLE-OH is used as a sedative in anesthesia to induce a state of deep relaxation and pain relief during surgical procedures. Its high potency and long duration of action make it an effective adjunct to other anesthetic agents in managing pain and ensuring patient comfort during surgery.
Used in Research:
BZ-NLE-OH is also used in scientific research as a tool to study the mechanisms of opioid action and develop new therapeutic agents with improved safety profiles. Its high affinity for the μ-opioid receptors makes it a valuable compound for investigating the role of these receptors in pain perception and addiction.

InChI:InChI=1/C13H17NO3/c1-2-3-9-11(13(16)17)14-12(15)10-7-5-4-6-8-10/h4-8,11H,2-3,9H2,1H3,(H,14,15)(H,16,17)/t11-/m0/s1

Upstream product

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Relevant academic research and scientific papers

Pd-catalyzed enantioselective C-H iodination: Asymmetric synthesis of chiral diarylmethylamines

An enantioselective C-H iodination reaction using a mono-N-benzoyl- protected amino acid has been developed for the synthesis of chiral diarylmethylamines. The reaction uses iodine as the sole oxidant and proceeds at ambient temperature and under air.

Asymmetric synthesis of α-(heteroaryl)alkylamines and α-amino acids via nucleophilic 1,2-addition of lithiated heterocycles to aldehyde SAMP-hydrazones

The asymmetric synthesis of α-(heteroaryl)alkylamines was accomplished by employing a diastereoselective nucleophilic 1,2-addition of lithiated aromatic heterocycles to aldehyde SAMP-hydrazones, followed by BH 3·THF or SmI2 promoted removal of the chiral auxiliary. The CBz or benzoyl-protected amines were obtained in good yields (40%-78%) and excellent enantiomeric excesses (ee = 88%-99%). The methodology can be applied to the synthesis of highly enantioenriched α-amino acids (ee = 90%-99%). TUeBITAK.

Diastereoselective Addition of Organometallic Reagents to Imines or Hydrazones Containing 1,3-Oxathiane As a Chiral Template

The addition of organometallic reagents to imines or hydrazones containing 1,3-oxathiane as a chiral auxiliary proceeded with high diastereoselectivity and can be used as a key reaction for the preparation of chiral β-amino alcohols.

HYDROXY SUBSTITUTED UREIDO AMINO AND IMINO ACIDS

Compounds of the formula STR1 are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase

SUBSTITUTED PROLINE COMPOUNDS, COMPOSITION AND METHOD OF USE

Compounds of the formula STR1 are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.

SUBSTITUTED PEPTIDE COMPOUNDS

Substituted peptide compounds of the formula STR1 are disclosed. These compounds are useful as hypotensive agents due to their angiotensin converting enzyme inhibition activity and depending upon the definition of X may also be useful as analgesics due to their enkephalinase inhibition activity.