54449-47-7Relevant articles and documents
Method for synthesizing amide compounds by using N-Boc amide as substrate
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Paragraph 0202-0210, (2020/01/12)
The invention relates to a method for synthesizing amide compounds by using N-Boc amide as a substrate. According to the method, N-Boc amide and various amine compounds are subjected to an intermolecular nucleophilic substitution reaction in an organic solvent so as to efficiently prepare various amide compounds. The method has the advantages of mild reaction conditions, simple and convenient operation, high yield and good functional group compatibility.
Tert -Butyl Peroxybenzoate Mediated Selective and Mild N-Benzoylation of Ammonia/Amines under Catalyst- and Solvent-Free Conditions
Yadav, Dilip Kumar T.,Bhanage, Bhalchandra M.
supporting information, p. 1862 - 1866 (2015/08/06)
A new protocol for the synthesis of amides from tert-butyl peroxybenzoate (TBPB) and ammonia/amines has been developed under catalyst- and solvent-free conditions. The ammonia, primary and secondary amines reacted smoothly with TBPB to furnish the corresponding primary, secondary, and tertiary amides in excellent yields. TBPB proved to be an efficient and highly chemoselective benzoylating reagent for aliphatic amines in the presence of aromatic amines/hydroxyl groups.
Selective formation of secondary amides via the copper-catalyzed cross-coupling of alkylboronic acids with primary amides
Rossi, Steven A.,Shimkin, Kirk W.,Xu, Qun,Mori-Quiroz, Luis M.,Watson, Donald A.
supporting information, p. 2314 - 2317 (2013/06/05)
For the first time, a general catalytic procedure for the cross-coupling of primary amides and alkylboronic acids is demonstrated. The key to the success of this reaction was the identification of a mild base (NaOSiMe3) and oxidant (di-tert-butyl peroxide) to promote the copper-catalyzed reaction in high yield. This transformation provides a facile, high-yielding method for the monoalkylation of amides.
