54458-30-9

Upstream product

• 25855-99-6 1-(4-methylphenyl)-3-phenyl-1,3-propanedione 
• 88039-22-9 2-bromo-3-imino-1-phenyl-N,3-di-p-tolylprop-1-enamine 
• 4224-96-8 3-phenyl-1-p-tolylprop-2-en-1-one 
• 10325-65-2 2,3-Dibromo-3-phenyl-1-p-tolyl-propan-1-one 
• 71443-43-1 N-(3-amino-1-phenyl-3-p-tolyl-allylidene)-4-methyl-aniline 
• 4224-87-7 4-methyl-chalcone 

Downstream Products

• 54458-33-2 1-phenyl-3-(p-tolyl)propane-1,2,3-trione 

Relevant academic research and scientific papers

Solvent-Controlled α-Monobromination, α,α-Dibromination or Imidation of 1,3-Diketones with N-Bromosuccinimide

In this work, we present a solvent-controlled regioselective method for α-monobromination, dibromination or imidation of 1,3-diketones with N-bromosuccinimide under simple reaction conditions. The employment of solvents plays a key role on the reaction selectivity providing α-monobrominated, dibrominated and imidated products. Visible light irradiation accelerates the dibromination reaction of 1,3-diketones. In particular, one important solvent was found to be highly effective for the imidation of 1,3-diketones under base-free condition.

Preparation method for 2-halogenated-1,3-dicarbonyl derivative

The invention discloses a preparation method for a 2-halogenated-1,3-dicarbonyl derivative. The preparation method is suitable for wide 1,3-dicarbonyl derivatives. The raw materials are easy to obtain, and multiple varieties are achieved. The product obtained through the method is diversified in type, and can be directly used and used for other further reactions. According to the method, reaction conditions are gentle, the reaction operation and after-treatment process is simple, reaction time is short, the yield is high, pollution is low, and the preparation method is suitable for industrial production.

Imidazo[2,1-b]thiazole derivatives XII. Synthesis and immunoactivity in vitro on human T lymphocyte of several 3-aroylmethyl and 2-aroyl-3-methyl(aryl)-5,6-dihydroimidazo[2,1-b]thiazoles

To estimate the influence of aryl group position on the immunostimulant properties of imidazo[2,1-b]thiazole derivatives, several compounds were obtained and tested, versus tetramisole hydrochloride, on the mobilisation of CD2 receptor by human T lymphocyte. The synthesis use the action of monobrominated β-diketones on the 2-mercaptoimidazoline. So, 1-aryl-4-bromobutane-1,3-diones lead to 3-aroylmethyl-5,6-dihydroimidazo[2,1-b]thiazoles 4. Same, 1-aryl-2-bromobutane-1,3-diones and 1,3-diaryl-2-bromopentane-1,3-diones give respectively 3-aroyl-2-methyl-5,6-dihydroimidazo[2,1-b]thiazoles 5 and 3-aroyl-2-aryl-5,6-dihydroimidazo[2,1-b]thiazoles 6. Better yields are obtained when the reaction presents two steps. The first one, realized in acetone at room temperature, leads to an intermediate S-substituted 4,5-dihydroimidazole which, in second step, is cyclized in imidazo[2,1-b]thiazole compound via an unisolated carbinolamine. This one explains the univocal formation of 5 derivatives and the feasible blending in case of 6. The immunoactivity of several imidazothiazoles 4, 5 and 6 is lower that them of 6-aryl substituted compounds and particularly that the levamisole which is the reference product in this series.

A Useful Synthesis of 3-Halogeno-1-azabutadiene Derivatives, and Their Applicability in the Preparation of Heterocycles

Azabutadiene derivatives (1) are halogenated in a selective manner with N-chlorosuccinimide or N-bromosuccinimide at the Cβ-enamine carbon.The resultant halogenated compounds (3) are suitable precursors for the synthesis of 2-oxopyrimidines and