849240-69-3

Upstream product

• 544686-86-4 diisopropyl-phosphoramidous acid benzyl ester 3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propyl ester 
• 544686-87-5 (S)-(-)-1-allyl-3-tert-butyldiphenylsilyl-sn-glycerol 
• 544686-85-3 2-O-(4-methoxybenzyl)-1-O-(tert-butyldiphenylsilyl)-sn-glycerol 
• 544686-84-2 3-O-allyl-2-O-(4-methoxybenzyl)-1-O-(tert-butyldiphenylsilyl)-sn-glycerol 

Downstream Products

• 849240-70-6 benzyl [(2S)-1,2-di-benzyloxy-propan-3-yl] [(2R)-1-hydroxy-2-(4-methoxybenzyloxy)propan-3-yl] phosphate 
• 849240-71-7 Phosphoric acid benzyl ester (S)-3-{benzyloxy-[(R)-3-(tert-butyl-diphenyl-silanyloxy)-2-(4-methoxy-benzyloxy)-propoxy]-phosphoryloxy}-2-(4-methoxy-benzyloxy)-propyl ester (S)-2,3-bis-benzyloxy-propyl ester 
• 849240-72-8 Phosphoric acid benzyl ester (R)-3-[benzyloxy-((S)-2,3-bis-benzyloxy-propoxy)-phosphoryloxy]-2-(4-methoxy-benzyloxy)-propyl ester (R)-3-hydroxy-2-(4-methoxy-benzyloxy)-propyl ester 

Relevant academic research and scientific papers

Synthesis of structural variants of Staphylococcus aureus lipoteichoic acid (LTA)

Based on 1,2-O-isopropylidene-sn-glycerol, which is readily available from d-mannitol, five chiral building blocks for the construction of structural variants of Staphylococcus aureus LTA designed and synthesized. Ligation of these building blocks led readily to the target molecules 1 and 2. They demonstrated that the d-alanine residues at the glycerophosphate backbone are decisive for the activation of the immune system.

Synthesis of the first fully active lipoteichoic acid

Nature outfoxed! Owing to the sensitivity of lipoteichoic acids (LTAs) to hydrolysis their biological activity could not be ascertained thus far. The chemical synthesis of LTA of Staphylococcus aureus 1, which contains hydrolytically labile D-alanine resi