123-34-2Relevant articles and documents
Synthesis of Phospholipids using an Inverse Phosphite Triester Approach
Hebert, Normand,Just, George
, p. 1497 - 1498 (1990)
1,2-Diacylglycerols, prepared from allyl protected precursors, were transformed into glycerophosphatidylcholines through an acid catalysed coupling with a dialkyl phosphoramidite, followed by a one step deprotection-substitution reaction.
Synthesis of a plasmenylethanolamine
Asano, Yoshio,Enomoto, Masaru,Inoue, Tsubasa,Kuwahara, Shigefumi,Maeda, Satoshi,Mohri, Tomoyo,Nakagawa, Kiyotaka,Ogura, Yusuke,Otoki, Yurika
, p. 1383 - 1389 (2021)
A concise synthesis of a plasmenylethanolamine (PlsEtn-[16:0/18:1 n-9]), known as antioxidative phospholipids commonly found in cell membranes, has been achieved from an optically active known diol through 8 steps. The key transformations for the synthesis of PlsEtn-[16:0/18:1 n-9] are (1) regio- A nd Z-selective vinyl ether formation via the alkylation of a lithioalkoxy allyl intermediate with an alkyl iodide, and (2) a one-pot phosphite esterification-oxidation sequence to construct the ethanolamine phosphonate moiety in the presence of the vinyl ether functionality. The piperidine salt of synthetic PlsEtn-[16:0/18:1 n-9] was desalinated through reversed-phase high-performance liquid chromatography purification.
Room-temperature self-healing polymers based on dynamic-covalent boronic esters
Cash, Jessica J.,Kubo, Tomohiro,Bapat, Abhijeet P.,Sumerlin, Brent S.
, p. 2098 - 2106 (2015)
Cross-linked polymers constructed with dynamic-covalent boronic esters were synthesized via photoinitiated radical thiol-ene click chemistry. Because the reversibility of the boronic ester cross-links was readily accessible, the resulting materials were capable of undergoing bond exchange to covalently mend after failure. The reversible bonds of the boronic esters were shown to shift their exchange equilibrium at room temperature when exposed to water. Nevertheless, the materials were observed to be stable and hydrophobic and absorbed only minor amounts of water over extended periods of time when submerged in water or exposed to humid environments. The facile reversibility of the networks allowed intrinsic self-healing under ambient conditions. Highly efficient self-healing of these bulk materials was confirmed by mechanical testing, even after subjecting a single site to multiple cut-repair cycles. Several variables were considered for their effect on materials properties and healing, including cross-link density, humidity, and healing time.
Zwitterionic Quaternary Ammonium Alkoxides: Organic Strong Bases
Lovett, Eva G.
, p. 2755 - 2758 (1991)
Stable quaternary ammonium alkoxides, a new type of organic strong base, were obtained from unhindered tertiary alkanolamines and glycidol.At elevated temperatures, the 2-hydroxyethyl derivatives underwent intramolecular rearrangements and deoxyalkylation to form tertiary amine terminated 1,4-poly(3-hydroxyoxetanes).Demethylation was also observed.The 3-hydroxypropyl derivative underwent disproportionation and Hofmann elimination in addition.
Synthesis and Evaluation of New Polyurethane - Based Material for Ion Separation
Favre-Reguillon, Alain,Dumont, Nathalie,Dunjic, Branko,Lemaire, Marc
, p. 6439 - 6442 (1995)
The polyaddition of macrocyclic diols with diisocyanates is an easy way to prepare ionselective polymers bearing pendant crown ethers.Those polymers can be readily immobilized on silicagel, with no change of ionselective properties.
Macrocyclic MCL-1 inhibitors and methods of use
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Paragraph 1049, (2019/02/28)
The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).
Bifunctional organocatalysts for the conversion of CO2, epoxides and aryl amines to 3-aryl-2-oxazolidinones
Xie, Ya-Fei,Guo, Cheng,Shi, Lei,Peng, Bang-Hua,Liu, Ning
supporting information, p. 3497 - 3506 (2019/04/14)
A route to synthesize 3-aryl-2-oxazolidinones is developed, which is achieved through a three component reaction between CO2, aryl amines, and epoxides with a binary organocatalytic system composed of organocatalysts and DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). The method allows wide scopes of epoxide and aryl amine substrates with various functional groups under mild reaction conditions. The control experiments indicate that a cyclic carbonate is formed via cycloaddition of epoxides with CO2, which further reacts with the β-amino alcohol originating from epoxides and aryl amines, resulting in the formation of 3-aryl-2-oxazolidinones finally.
