54530-94-8Relevant academic research and scientific papers
Synthetic method for 4-chloro-8-aminoquinoline
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Paragraph 0005; 0008, (2016/11/17)
The invention relates to a synthetic method for 4-chloro-8-aminoquinoline, belonging to the technical field of organic chemical synthesis. The method comprises the following steps: firstly adding benzene into concentrated sulfuric acid and carrying out sulfonation so as to obtain benzene sulfonic acid, then subjecting benzene sulfonic acid to mixing with water, polyethylene glycol and nitric acid, carrying out heating and stirring with zinc chloride, then carrying out reaction with iron and hydrochloric acid under stirring, carrying out anaerobic fermentation and desulfurization, then subjecting obtained fermented substances and chloropropanol to mixing and stirring, and finally carrying out reduction reaction so as to obtain the 4-chloro-8-aminoquinoline. The invention has the following beneficial effects: the synthetic method provided by the invention has simple operation steps and mild reaction conditions, can generate strong fluorescent characteristic in application process of the 4-chloro-8-aminoquinoline at the same time, and can be applied in detection of the contents of metal ions.
