54544-05-7Relevant articles and documents
Cannabidiol derivative, preparation method and application thereof
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, (2021/07/28)
The invention discloses a cannabidiol derivative, a preparation method and application thereof, and belongs to the technical field of medicinal chemistry, wherein the cannabidiol derivative is obtained by taking cannabidiol as a main body through a synthesis means, and an anti-tumor activity determination result shows that the cannabidiol derivative prepared by the invention has an inhibition effect on lung cancer cell strains, human breast cancer cell strains, nasopharynx cancer and drug-resistant strains thereof.
Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors
Zhang, Renshuai,Yu, Rilei,Xu, Qi,Li, Xiangqian,Luo, Jiao,Jiang, Bo,Wang, Lijun,Guo, Shuju,Wu, Ning,Shi, Dayong
supporting information, p. 24 - 33 (2017/04/11)
Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of insulin signaling pathway. Inhibition of PTP1B is expected to improve insulin action. Appropriate selectivity and permeability are the gold standard for excellent PTP1B inhibitors. In this work, molecular hybridization-based screening identified a selective competitive PTP1B inhibitor. Compound 10a has IC50 values of 199?nM against PTP1B, and shows 32-fold selectivity for PTP1B over the closely related phosphatase TCPTP. Molecule docking and molecular dynamics studies reveal the reason of selectivity for PTP1B over TCPTP. Moreover, the cell permeability and cellular activity of compound 10a are demonstrated respectively.
Efficient synthesis of the siderophore petrobactin via antimony triethoxide mediated coupling
Pandey, Rajesh K.,Jarvis, Gregory G.,Low, Philip S.
scheme or table, p. 1627 - 1629 (2012/04/17)
Chemical synthesis of petrobactin, a siderophore for Bacillus anthracis, has been achieved via Sb(OEt)3-mediated ester-amide exchange.