4143-64-0

Basic information

• Product Name: 3',4'-DIHYDROXYFLAVONE
• Synonyms: 3',4'-DIHYDROXYFLAVONE;4-HYDROXYFLAVONOL;DIHYDROXYFLAVONE, 3',4'-;3',4'-Dihydroxyflavone,97%;DIHYDROXYFLAVONE, 3',4'-(RG);3',4'-Dihydroxyflavone;2-(3,4-dihydroxyphenyl)chromen-4-one;2-(3,4-dihydroxyphenyl)chromone
• CAS NO: 4143-64-0
• Molecular Formula: C₁₅H₁₀O₄
• Molecular Weight: 254.24
• Product Categories: Di-substituted Flavones
• Mol File: 4143-64-0.mol
• Article Data: 7

Chemical Properties

• Melting Point: 251-253°C
• Boiling Point: 482.3 °C at 760 mmHg
• Flash Point: 188.4 °C
• Appearance: /
• Density: 1.443
• PKA: 8.29±0.18(Predicted)
• BRN: 212540
• CAS DataBase Reference: 3',4'-DIHYDROXYFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3',4'-DIHYDROXYFLAVONE(4143-64-0)
• EPA Substance Registry System: 3',4'-DIHYDROXYFLAVONE(4143-64-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 4143-64-0(Hazardous Substances Data)

Upstream product

• 53906-83-5 3'-methoxyflavone 
• 4143-74-2 4'-methoxyflavone 
• 54544-05-7 3,4-bis-benzyloxybenzoic acid methyl ester 
• 99-50-3 3,4-Dihydroxybenzoic acid 
• 134178-06-6 methyl 3,4-bis<(tert-butyldimethylsilyl)oxy>benzoate 
• 2150-43-8 3,4-dihydroxybenzoic acid methyl ester 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 118-93-4 o-hydroxyacetophenone 
• 19152-36-4 (E)-2'-hydroxy-3,4-dimethoxychalcone 
• 4143-62-8 3',4'-dimethoxyflavone 

Downstream Products

• 6068-78-6 3,3',4'-trihydroxyflavone 
• 517892-06-7 3',4'-dihydroxyflavone-4'-phosphate 

Relevant articles and documents

Preference for O-demethylation reactions in the oxidation of 2′-, 3′-, and 4′-methoxyflavones by human cytochrome P450 enzymes

2′-, 3′-, and 4′-Methoxyflavones (MeFs) were incubated with nine forms of recombinant human cytochrome P450 (P450 or CYP) enzymes in the presence of an NADPH-generating system and the products formed were analyzed with LC-MS/MS methods. CYP1B1.1 and 1B1.3

Synthetic studies of fisetin, myricetin and nobiletin analogs and related probe molecules

We synthesized a series of analogs of fisetin, myricetin and nobiletin, as well as related fluorescein- and biotin-based flavone-probe molecules, on a suitable scale for biological and structure-activity relationship studies.

Synthesis and antihepatotoxic activity of some heterocyclic compounds containing the 1,4-dioxane ring system

Silymarin isolated from Silybum marianum is a mixture of three isomers, silybin (1), silydianin (2) and silychristin (3). Silybin is the most active antihepatotoxic agent, and contains a 1,4-dioxane ring in addition to a flavonoid moiety. Based on the skeleton of silybin, we prepared some flavones and coumarins containing the 1,4-dioxane ring system and evaluated them for antihepatotoxic activity against carbon tetrachloride induced hepatotoxicity in albino rats. The degree of protection was determined by measuring biochemical parameters such as serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvate transaminase (SGPT), alkaline phosphatase (ALKP), total protein (TP) and total albumin (TA). The compounds namely 3′,4′(1″,4″-dioxino) flavone (4f), and 3′,4′(2-hydroxy methyl, 1′,4″-dioxino) flavone (4g) were found to exhibit a significant activity comparable to standard drug silymarin (silybon-70). Other compounds also exhibited good activity. The structure activity relationship (SAR) was also studied, and where the flavonoid analogues containing a hydroxy methyl group at position-2″ in the dioxane ring exhibited superior antihepatotoxic activity in comparison to coumarin derivatives.