54549-90-5

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• 13389-42-9 trans-2-Octene 
• 480-91-1 oxisoindole 
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• 108-94-1 cyclohexanone 
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• 3761-92-0 n-hexylmagnesium bromide 
• 17475-09-1 2-<1-Methylhepten-(1)-yl>-phenol 

Relevant academic research and scientific papers

Branched-Selective Direct α-Alkylation of Cyclic Ketones with Simple Alkenes

Herein, we describe an intermolecular direct branched-selective α-alkylation of cyclic ketones with simple alkenes as the alkylation agents. Through an enamine-transition metal cooperative catalysis mode, the α-alkylation is realized in an atom- and step-economic manner with excellent branched selectivity for preparing β-branched ketones. Employment of a pair of bulky Br?nsted acid and base as additives is responsible for enhanced efficiency. Promising enantioselectivity (74 % ee) has been obtained. Experimental and computational mechanistic studies suggest that a pathway through alkene migratory insertion into the Ir?C bond followed by C?H reductive elimination is involved for the high branched selectivity.

Branched-selective intermolecular ketone α-alkylation with unactivated alkenes via an enamide directing strategy

We describe a strategy for intermolecular branched-selective α-alkylation of ketones using simple alkenes as the alkylating agents. Enamides derived from isoindolin-1-one provide an excellent directing template for catalytic activation of ketone α-positions. High branched selectivity is obtained for both aliphatic and aromatic alkenes using a cationic iridium catalyst. Preliminary mechanistic study favors an Ir-C migratory insertion pathway.

Process for the preparation of organic compounds with manganese cataylsts or the like

A process of the present invention produces an organic compound by allowing a compound containing an electron attractive group of following Formula (1): 1wherein Y is an electron attractive group; and Rb and Rc are each a hydrogen atom or an organic group, where Y, Rb and Rc may respectively be combined with each other to form a ring with an adjacent carbon atom, to react with a compound containing an unsaturated carbon-carbon bond of following Formula (2) or 2wherein Rd, Re, Rf, Rg, Ri and Rj are each a hydrogen atom or an organic group, where Rd, Re, Rf and Rg may respectively be combined to form a ring with one or two adjacent carbon atoms, and Ri and Rj may be combined to form a ring with adjacent two carbon atoms, in the presence of oxygen and a catalytic compound of a Group 5, 6, 7, 8 or 9 element of the Periodic Table of Elements to yield a compound of following Formula (3) or (8): 3wherein Z is a hydrogen atom or a hydroxyl group; and Y, Rb, Rc, Rd, Re, Rf, Rg, Ri and Rj have the same meanings as defined above. This process can efficiently produce a compound having an alkyl group or alkenyl group bonded at the alpha position of an electron attractive group, or a derivative thereof, by catalytic radical addition reaction.

PROCESS FOR THE PREPARATION OF ORGANIC COMPOUNDS WITH MANGANESE CATALYSTS OR THE LIKE

A process of the present invention produces an organic compound by allowing a compound containing an electron attractive group of following Formula (1):wherein Y is an electron attractive group; and Rb and Rc are each a hydrogen atom or an organic group, where Y, Rb and Rc may respectively be combined with each other to form a ring with an adjacent carbon atom, to react with a compound containing an unsaturated carbon-carbon bond of following Formula (2) or (7):wherein Rd, Re, Rf, Rg, Ri and Rj are each a hydrogen atom or an organic group, where Rd, Re, Rf and Rg may respectively be combined to form a ring with one or two adjacent carbon atoms, and Ri and Rj may be combined to form a ring with adjacent two carbon atoms, in the presence of oxygen and a catalytic compound of a Group 5, 6, 7, 8 or 9 element of the Periodic Table of Elements to yield a compound of following Formula (3) or (8):wherein Z is a hydrogen atom or a hydroxyl group; and Y, Rb, Rc, Rd, Re, Rf, Rg, Ri and Rj have the same meanings as defined above. This process can efficiently produce a compound having an alkyl group or alkenyl group bonded at the alpha position of an electron attractive group, or a derivative thereof, by catalytic radical addition reaction.