5457-19-2

Basic information

• Product Name: 5-methyloxolane-2,4-dione
• Synonyms: 5-methyloxolane-2,4-dione
• CAS NO: 5457-19-2
• Molecular Formula: C₅H₆O₃
• Molecular Weight: 114.1
• Mol File: 5457-19-2.mol

Chemical Properties

• Melting Point: 115 °C
• Boiling Point: 291.1°Cat760mmHg
• Flash Point: 132.1°C
• Appearance: /
• Density: 1.23g/cm³
• Vapor Pressure: 0.00199mmHg at 25°C
• Refractive Index: 1.452
• PKA: 10.71±0.40(Predicted)
• CAS DataBase Reference: 5-methyloxolane-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyloxolane-2,4-dione(5457-19-2)
• EPA Substance Registry System: 5-methyloxolane-2,4-dione(5457-19-2)

Safety Data

• Hazardous Substances Data: 5457-19-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C5H6O3/c1-3-4(6)2-5(7)8-3/h3H,2H2,1H3

Upstream product

• 7647-01-0 hydrogenchloride 
• 100251-13-6 (2-acetoxy-propionyl)-malonic acid diethyl ester 
• 7664-93-9 sulfuric acid 
• 4949-44-4 ethyl propanoylacetate 
• 16533-81-6 (+/-)-2-bromo-4-hydroxy-3-oxo-valeric acid-lactone 
• 20918-92-7 (R)-2-(Acetoxy)propionsaeure-ethylester 
• 16533-81-6 (4R)-2-bromo-4-hydroxy-3-oxo-valeric acid-lactone 

Downstream Products

• 92541-06-5 2-(2-Benzyloxy-3,4-dimethoxy-phenyl)-3,4,7-trimethyl-7H-furo[3,4-b]pyridin-5-one 
• 92541-07-6 2-(2-Benzyloxy-3,4-dimethoxy-phenyl)-3,7-dimethyl-5-oxo-5,7-dihydro-furo[3,4-b]pyridine-4-carbaldehyde 
• 92562-99-7 4-Acetyl-6-(2-benzyloxy-3,4-dimethoxy-phenyl)-7-methyl-pyrrolo[3,4-c]pyridine-1,3-dione 
• 92541-10-1 2-(2-Benzyloxy-3,4-dimethoxy-phenyl)-3-methyl-7-methylene-5-oxo-5,7-dihydro-furo[3,4-b]pyridine-4-carboxylic acid methyl ester 
• 92562-97-5 2-(2-Benzyloxy-3,4-dimethoxy-phenyl)-3,7-dimethyl-5-oxo-5,7-dihydro-furo[3,4-b]pyridine-4-carboxylic acid 
• 92541-14-5 2-(2-Benzyloxy-3,4-dimethoxy-phenyl)-3,7-dimethyl-5-oxo-5,7-dihydro-furo[3,4-b]pyridine-4-carboxylic acid amide 
• 92541-15-6 6-(2-Benzyloxy-3,4-dimethoxy-phenyl)-4-(1-hydroxy-ethyl)-7-methyl-pyrrolo[3,4-c]pyridine-1,3-dione 
• 92541-08-7 2-(2-Benzyloxy-3,4-dimethoxy-phenyl)-3,7-dimethyl-5-oxo-5,7-dihydro-furo[3,4-b]pyridine-4-carboxylic acid methyl ester 
• 92541-11-2 2-(2-Benzyloxy-3,4-dimethoxy-phenyl)-7-hydroxy-3,7-dimethyl-5-oxo-5,7-dihydro-furo[3,4-b]pyridine-4-carboxylic acid methyl ester 
• 92541-09-8 2-(2-Benzyloxy-3,4-dimethoxy-phenyl)-3,7-dimethyl-5-oxo-1-oxy-5,7-dihydro-furo[3,4-b]pyridine-4-carboxylic acid methyl ester 
• 92562-98-6 6-(2-Benzyloxy-3,4-dimethoxy-phenyl)-2-(6-hydroxy-quinolin-2-yl)-5-methyl-pyridine-3,4-dicarboxylic acid dimethyl ester 
• 92541-13-4 6-(2-Benzyloxy-3,4-dimethoxy-phenyl)-2-(6-methoxy-5-nitro-quinolin-2-yl)-5-methyl-pyridine-3,4-dicarboxylic acid dimethyl ester 
• 92541-12-3 6-(2-Benzyloxy-3,4-dimethoxy-phenyl)-2-[6-(4-methoxy-benzyloxy)-quinolin-2-yl]-5-methyl-pyridine-3,4-dicarboxylic acid dimethyl ester 
• 867068-74-4 9-(3,5-dimethoxyphenyl)-6-methyl-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one 

Relevant articles and documents

Peniphenone and Penilactone Formation in Penicillium crustosum via 1,4-Michael Additions of ortho-Quinone Methide from Hydroxyclavatol to γ-Butyrolactones from Crustosic Acid

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(R)-(+)-Carolinic acid was prepared in seven steps and 59% yield from inexpensive benzyl l-lactate, the configuration of which was inverted by a Mitsunobu reaction with trifluoroacetate. The resulting benzyl d-lactate was cyclised by a domino addition-Wittig alkenation reaction with Ph3PCCO. The product tetronic acid was acylated with a second equivalent of this ylide to give a 3-acylylidenetetronic acid, which was olefinated directly with tert-butyl glyoxylate. The product alkene was hydrogenated and deprotected to afford pure crystalline (R)-(+)-carolinic acid, which proved inactive against Staphylococcus aureus and Escherichia coli mutant D21f2.

Methods of inhibiting the advanced glycosylation of proteins using tetramic and tetronic acids and compositions therefor

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